Protein Alignment Tsp42Ei and Tspan14

DIOPT Version :10

• Sequence 1: NP_523635.2
• Gene: Tsp42Ei / 35618
• FlyBaseID: FBgn0033130
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_666040.1
• Gene: Tspan14 / 52588
• MGIID: 1196325
• Length: 270
• Species: Mus musculus
• Alignment Length: 248
• Identity: 59/248 - (23%)
• Similarity: 95/248 - (38%)
• Gaps: 67/248 - (27%)

  Fly     9 KHVLLLLNFVFSVLGLALIAFGIFFLISAAENAV-----------SIGKNVAGGLIIALGVVILI 62
            |::|...|.||.:.|:..:..|::   :.:|..|           .|...|   |::.:|||:..
Mouse    16 KYLLFSYNIVFWLAGVVFLGVGLW---AWSEKGVLSDLTKVTRLHGIDPVV---LVLMVGVVMFT 74

  Fly    63 IAIFGCLAAIHEAPVRLLIYVGAVVL-----LILAQLIFLGMSSHGTKDGISGSINEGFDRLWES 122
            :...||:.|:.|....|..:.||:||     |.:|.|.||      .:|.:.....|.|:...:|
Mouse    75 LGFAGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFL------FQDWVRDRFREFFESNIKS 133

  Fly   123 ERNQTGALSYYESWL---QCCGVNSSEDYWIIH--------------HGIPSSCC---PESKCMD 167
            .|:.....:..:|..   ||||....|| |.::              .|:|.|||   |..|.::
Mouse   134 YRDDIDLQNLIDSLQKANQCCGAYGPED-WDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVN 197

  Fly   168 T--------------PSRVFKTGCKAAFVKYLDDKLL----VFKIVCWLLVIG 202
            |              ...:|..||..|...:|...:.    ||..:..|.:.|
Mouse   198 TQCGYDVRIQLKSKWDEFIFTKGCIQALEGWLPRNIYIVAGVFIAISLLQIFG 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ei	NP_523635.2	Tetraspanin	8..214	CDD:459767	59/248 (24%)
Tspan14	NP_666040.1	Tetraspanin	16..258	CDD:459767	59/248 (24%)
		TM4SF9_like_LEL	113..233	CDD:239412	28/126 (22%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000250|UniProtKB:Q8NG11	114..232		27/124 (22%)