DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tsp42Eh and CD63

DIOPT Version :9

Sequence 1:NP_523634.1 Gene:Tsp42Eh / 35617 FlyBaseID:FBgn0033129 Length:231 Species:Drosophila melanogaster
Sequence 2:NP_001244318.1 Gene:CD63 / 967 HGNCID:1692 Length:238 Species:Homo sapiens


Alignment Length:246 Identity:60/246 - (24%)
Similarity:98/246 - (39%) Gaps:43/246 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYCTTRLLRYVLCVISGICALGGCLLIWYGAWLLDSLSEEQRMLGMDHGEDLAAVLCVLLGTVIV 65
            |.| .:.|.|||.:....||: |.:.:..||.|:.|.:..|   |...| .|..|:.:.:|..:.
Human     7 MKC-VKFLLYVLLLAFCACAV-GLIAVGVGAQLVLSQTIIQ---GATPG-SLLPVVIIAVGVFLF 65

  Fly    66 VASIFGSVAVAKDSRVLLICYAVLLVFLLIVQIVLVSISYAASRDFLPD---SLRQGLDDLWDLQ 127
            :.:..|.....|::..|:|.:|:.|..:::|::......|......:.:   :.||.:::.....
Human    66 LVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNN 130

  Fly   128 HEGNSTLNTYEEWLHCCGRNSAEDYLHLEKMP-------PPSCCLNRDCTKHLNLFMTGCEVKFK 185
            |.. |.|:..:....|||   |.:|...||:|       |.|||:|         ...||.:.|.
Human   131 HTA-SILDRMQADFKCCG---AANYTDWEKIPSMSKNRVPDSCCIN---------VTVGCGINFN 182

  Fly   186 EYVGAKTANFHSL-SWF-------------LVIFEFAGSVTTCYLVDSIRN 222
            |....|......: .|.             :...|..|.|..|.||.|||:
Human   183 EKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRS 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tsp42EhNP_523634.1 Tetraspannin 8..220 CDD:278750 55/235 (23%)
tetraspanin_LEL 109..192 CDD:239401 22/92 (24%)
CD63NP_001244318.1 Tetraspannin 10..227 CDD:395265 53/234 (23%)
CD63_LEL 105..203 CDD:239419 25/110 (23%)
Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731 234..238 60/246 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3882
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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