Protein Alignment Tsp42Eh and TSPAN14

DIOPT Version :10

• Sequence 1: NP_523634.1
• Gene: Tsp42Eh / 35617
• FlyBaseID: FBgn0033129
• Length: 231
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 47/204 - (23%)
• Similarity: 87/204 - (42%)
• Gaps: 48/204 - (23%)

  Fly    15 ISGICALGGCLLIWYGAWLLDSLSEEQRMLGMDHGEDLAAVLCVLLGTVIVVASIFGSVAVAKDS 79
            ::|:..||..|..|....:|..|::..||.|:|     ..||.:::|.|:......|.|...:::
Human    28 LAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGID-----PVVLVLMVGVVMFTLGFAGCVGALREN 87

  Fly    80 RVLL--ICYAVLLVFLLIVQIVLVSISYA-----ASRDFLPDSLRQGLDDLWDLQHEGNSTLNTY 137
            ..||  .|..::|:|.|.:.:.:::..:.     ..|:|...:::...||: |||    :.:::.
Human    88 ICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDI-DLQ----NLIDSL 147

  Fly   138 EEWLHCCGRNSAEDY-LHL-----------EKMPPP-SCCLNRDCTKHLN--------------- 174
            ::...|||....||: |::           ||...| |||:.....|.:|
Human   148 QKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKW 212

  Fly   175 ---LFMTGC 180
               :|..||
Human   213 DESIFTKGC 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eh	NP_523634.1	Tetraspanin	8..217	CDD:459767	47/204 (23%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	47/204 (23%)
		TM4SF9_like_LEL	113..233	CDD:239412	24/114 (21%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		24/113 (21%)