Protein Alignment Tsp42Eh and PRPH2

DIOPT Version :10

• Sequence 1: NP_523634.1
• Gene: Tsp42Eh / 35617
• FlyBaseID: FBgn0033129
• Length: 231
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 298
• Identity: 53/298 - (17%)
• Similarity: 90/298 - (30%)
• Gaps: 126/298 - (42%)

  Fly    30 GAWLLDSLSEEQRMLGMDHGEDLAAVLCVLLGTVIVVASIFGSVAVAKDSRVL------------ 82
            |.||::..|                   ||.|.:|....:|..:.:.|.|.|:
Human    19 GLWLMNWFS-------------------VLAGIIIFSLGLFLKIELRKRSDVMNNSESHFVPNSL 64

  Fly    83 ---------------LICY-------------------AVLLVFLLIVQIVLVSISYAASRDFLP 113
                           .|||                   |:.::|.:|  :.||::.....|..|.
Human    65 IGMGVLSCVFNSLAGKICYDALDPAKYARWKPWLKPYLAICVLFNII--LFLVALCCFLLRGSLE 127

  Fly   114 DSLRQGLDD----LWDLQHEG----NSTLNTYEEWLHCCGRNSAEDYLHLEKMP----------- 159
            ::|.|||.:    ..|....|    ..|::..:....|||.|...|:..::.:.
Human   128 NTLGQGLKNGMKYYRDTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEV 192

  Fly   160 -----------------PPSCC---LNRDC-----------------TKHLNLFMTGCEVKFKEY 187
                             |.|||   ..|.|                 |:.|||::.||......|
Human   193 KDRIKSNVDGRYLVDGVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSY 257

  Fly   188 VGAKTANFHSLSWFLVIFEFAGSVTTCYL---VDSIRN 222
            ..:...:...::..:.:||...::...||   :|.:.|
Human   258 YSSLMNSMGVVTLLIWLFEVTITIGLRYLQTSLDGVSN 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eh	NP_523634.1	Tetraspanin	8..217	CDD:459767	51/291 (18%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	34/182 (19%)
		peripherin_like_LEL	120..262	CDD:239415	27/141 (19%)
		Interaction with MREG. /evidence=ECO:0000250	341..346