Protein Alignment Tsp42Eg and TSPAN14

DIOPT Version :10

• Sequence 1: NP_523633.1
• Gene: Tsp42Eg / 35616
• FlyBaseID: FBgn0033128
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 186
• Identity: 49/186 - (26%)
• Similarity: 77/186 - (41%)
• Gaps: 32/186 - (17%)

  Fly    11 FALF-WDIILALFGLVVIGLGVHI---------IYKFE--HFNTAAFVIIAVGVVVVLTALFGAL 63
            :.|| ::||..|.|:|.:|:|:..         :.|..  |......:::.||||:......|.:
Human    17 YLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCV 81

  Fly    64 GAARESSATSKVF--VVILIVLVILEVLAVGFL---WV---FQTSLLINVDKTFDKLWNDQPVPI 120
            ||.||:......|  .::||..:.|.|..:.||   ||   |:.....|:....|.:
Human    82 GALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDI-------- 138

  Fly   121 KPGNQSQIASLERWLDCCGNVGPSDYILPPNSCYNGESDKLNLEGCRQKFLDFIAD 176
              ..|:.|.||::...|||..||.|:.|  |..:|......:.|.|...|...:.|
Human   139 --DLQNLIDSLQKANQCCGAYGPEDWDL--NVYFNCSGASYSREKCGVPFSCCVPD 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eg	NP_523633.1	Tetraspanin	17..204	CDD:459767	47/179 (26%)
		tetraspanin_LEL	95..176	CDD:239401	21/83 (25%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	49/186 (26%)
		TM4SF9_like_LEL	113..233	CDD:239412	24/90 (27%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		23/89 (26%)