Protein Alignment Tsp42Eg and PRPH2

DIOPT Version :10

• Sequence 1: NP_523633.1
• Gene: Tsp42Eg / 35616
• FlyBaseID: FBgn0033128
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_000313.2
• Gene: PRPH2 / 5961
• HGNCID: 9942
• Length: 346
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 59/305 - (19%)
• Similarity: 103/305 - (33%)
• Gaps: 120/305 - (39%)

  Fly    15 WDIILALFGLVVIGLGVHIIYKFE-------------HF--NTAAFVIIAVGVV-VVLTALFG-- 61
            |..:||  |:::..||:.:  |.|             ||  |:    :|.:||: .|..:|.|
Human    25 WFSVLA--GIIIFSLGLFL--KIELRKRSDVMNNSESHFVPNS----LIGMGVLSCVFNSLAGKI 81

  Fly    62 ---ALGAARESS---------ATSKVFVVILIVLVILEVLAVGFLWVFQTSLLINVDKTFDKLWN 114
               ||..|:.:.         |...:|.:||.::.:...|..|.|    .:.|....|...|.:.
Human    82 CYDALDPAKYARWKPWLKPYLAICVLFNIILFLVALCCFLLRGSL----ENTLGQGLKNGMKYYR 142

  Fly   115 DQPVPIKPGNQSQIASLERWLDCCGNVGPSD------------------------------YILP 149
            |...|.:...:..|..|:....||||.|..|                              |::.
Human   143 DTDTPGRCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVD 207

  Fly   150 --PNSC----------------------YNGESDKLNL--EGCRQKFLDFIADRWTTFNLVSLVL 188
              |.||                      |:.::::|||  .|||...|.:.:....:..:|:|::
Human   208 GVPFSCCNPSSPRPCIQYQITNNSAHYSYDHQTEELNLWVRGCRAALLSYYSSLMNSMGVVTLLI 272

  Fly   189 --------LGVELICALL--------------AYVLANSIVNRWR 211
                    :|:..:...|              .::|..|:...|:
Human   273 WLFEVTITIGLRYLQTSLDGVSNPEESESESQGWLLERSVPETWK 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eg	NP_523633.1	Tetraspanin	17..204	CDD:459767	56/294 (19%)
		tetraspanin_LEL	95..176	CDD:239401	25/136 (18%)
PRPH2	NP_000313.2	Tetraspanin	16..181	CDD:459767	40/167 (24%)
		peripherin_like_LEL	120..262	CDD:239415	28/145 (19%)
		Interaction with MREG. /evidence=ECO:0000250	341..346