Protein Alignment Tsp42Eg and TSPAN33

DIOPT Version :10

• Sequence 1: NP_523633.1
• Gene: Tsp42Eg / 35616
• FlyBaseID: FBgn0033128
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_848657.1
• Gene: TSPAN33 / 340348
• HGNCID: 28743
• Length: 283
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 60/270 - (22%)
• Similarity: 106/270 - (39%)
• Gaps: 72/270 - (26%)

  Fly     7 VLKGFALFWDIILALFGLVVIGLGVHIIYKFEHFNTA--------AFVIIAVGVVVVLTALFGAL 63
            ::|....|::::..:..:|::.:||: ....:|...|        |.::|.|||::.|....|.:
Human    21 LVKYLLFFFNMLFWVISMVMVAVGVY-ARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCI 84

  Fly    64 GAARESSATSKVFVVILIVLVILEVLAVGFL-WVFQTSLLINVDKTFDK---LWNDQPVPIKP-- 122
            |:.||:....:.|.:.|..:.:|: ||.|.| :||.       ||...|   :.|:..|..:.
Human    85 GSLRENICLLQTFSLCLTAVFLLQ-LAAGILGFVFS-------DKARGKVSEIINNAIVHYRDDL 141

  Fly   123 GNQSQIASLERWLDCCGNVGPSDY-----------------ILPPNSC----------------- 153
            ..|:.|...::...|||.:...|:                 ...|.||
Human   142 DLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQG 206

  Fly   154 -----YNGESDKLNLEGCRQKFLDFIADRWTTFNLVSL--VLLGV---ELICALLAYVLANSIVN 208
                 |...|..:...||..|.::     |...||..|  |.||:   :|:..||:.:|.|.|.:
Human   207 MQAFDYLEASKVIYTNGCIDKLVN-----WIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKD 266

  Fly   209 RWRRSKYYQK 218
            :.:...|.|:
Human   267 QIKLQLYNQQ 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eg	NP_523633.1	Tetraspanin	17..204	CDD:459767	54/244 (22%)
		tetraspanin_LEL	95..176	CDD:239401	21/124 (17%)
TSPAN33	NP_848657.1	Tetraspanin	22..262	CDD:459767	56/253 (22%)
		penumbra_like_LEL	116..236	CDD:239411	22/131 (17%)