Protein Alignment Tsp42Eg and Prph2

DIOPT Version :10

• Sequence 1: NP_523633.1
• Gene: Tsp42Eg / 35616
• FlyBaseID: FBgn0033128
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_032964.1
• Gene: Prph2 / 19133
• MGIID: 102791
• Length: 346
• Species: Mus musculus
• Alignment Length: 268
• Identity: 61/268 - (22%)
• Similarity: 101/268 - (37%)
• Gaps: 87/268 - (32%)

  Fly    15 WDIILALFGLVVIGLG----VHIIYKFEHFNTAA--FV---IIAVGVV-VVLTALFG-----ALG 64
            |..:||  |:|:..||    :.:..:.|..|.:.  ||   :|.|||: .|..:|.|     ||.
Mouse    25 WLSVLA--GIVLFSLGLFLKIELRKRSEVMNNSESHFVPNSLIGVGVLSCVFNSLAGKICYDALD 87

  Fly    65 AARESS---------ATSKVFVVILIVLVILEVLAVGFLWVFQTSLLINVDKTFDKLWNDQPVPI 120
            .|:.:.         |....|.|||.::.:...|..|.|   :::|...: |...|.:.|...|.
Mouse    88 PAKYAKWKPWLKPYLAVCIFFNVILFLVALCCFLLRGSL---ESTLAYGL-KNGMKYYRDTDTPG 148

  Fly   121 KPGNQSQIASLERWLDCCGNVGPSD------------------------------YILP--PNSC 153
            :...:..|..|:....||||.|..|                              |::.  |.||
Mouse   149 RCFMKKTIDMLQIEFKCCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRYLVDGVPFSC 213

  Fly   154 ----------------------YNGESDKLN--LEGCRQKFLDFIADRWTTFNLVSLVLLGVEL- 193
                                  |:.::::||  |.|||...|::.:....:..:|:|::...|:
Mouse   214 CNPSSPRPCIQYQLTNNSAHYSYDHQTEELNLWLRGCRAALLNYYSSLMNSMGVVTLLVWLFEVS 278

  Fly   194 ICALLAYV 201
            |.|.|.|:
Mouse   279 ITAGLRYL 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eg	NP_523633.1	Tetraspanin	17..204	CDD:459767	60/266 (23%)
		tetraspanin_LEL	95..176	CDD:239401	25/136 (18%)
Prph2	NP_032964.1	Tetraspanin	16..181	CDD:459767	42/161 (26%)
		peripherin_like_LEL	120..262	CDD:239415	28/145 (19%)
		Interaction with MREG. /evidence=ECO:0000269|PubMed:17260955	341..346