Protein Alignment Tsp42Ec and Tspan14

DIOPT Version :10

• Sequence 1: NP_523629.1
• Gene: Tsp42Ec / 35612
• FlyBaseID: FBgn0033124
• Length: 232
• Species: Drosophila melanogaster
• Sequence 2: NP_666040.1
• Gene: Tspan14 / 52588
• MGIID: 1196325
• Length: 270
• Species: Mus musculus
• Alignment Length: 268
• Identity: 58/268 - (21%)
• Similarity: 108/268 - (40%)
• Gaps: 67/268 - (25%)

  Fly    10 FILYIVNIVFLIVGILLIVLG------SIMLSDLSRFDVAGSGTDPNTIPICVTVLGGLIFVVSF 68
            ::|:..||||.:.|::.:.:|      ..:||||::. ....|.||   .:.|.::|.::|.:.|
Mouse    17 YLLFSYNIVFWLAGVVFLGVGLWAWSEKGVLSDLTKV-TRLHGIDP---VVLVLMVGVVMFTLGF 77

  Fly    69 FGCYGIFRQSVCMTGAYTSMVFVLFILQLVLTCWVFV---------------NRSAFLG--DMSN 116
            .||.|..|:::|:...:...:.::|.|:|.:....|:               |..::..  |:.|
Mouse    78 AGCVGALRENICLLKFFCGAIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQN 142

  Fly   117 LVNLL--------------WDSHDYTAMGVLEETFGCCGDTSYTNYNNIGLSVPGTCCGYLDRQA 167
            |::.|              ||.:.|         |.|.|    .:|:.....||.:||.....|.
Mouse   143 LIDSLQKANQCCGAYGPEDWDLNVY---------FNCSG----ASYSREKCGVPFSCCVPDPAQK 194

  Fly   168 TCNTPSVYQSRPGCSAKFEEF------------W-NDNMDIIRWSGLGLCIFDLVVFLIAGALTN 219
            ..||...|..|....:|::||            | ..|:.|:....:.:.:..:....:|..|.:
Mouse   195 VVNTQCGYDVRIQLKSKWDEFIFTKGCIQALEGWLPRNIYIVAGVFIAISLLQIFGIFLARTLIS 259

  Fly   220 CMRSQNAG 227
            .:.:..||
Mouse   260 DIEAVKAG 267

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ec	NP_523629.1	Tetraspanin	8..219	CDD:459767	56/258 (22%)
		tetraspanin_LEL	<137..192	CDD:351888	17/67 (25%)
Tspan14	NP_666040.1	Tetraspanin	16..258	CDD:459767	55/257 (21%)
		TM4SF9_like_LEL	113..233	CDD:239412	26/132 (20%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000250|UniProtKB:Q8NG11	114..232		25/130 (19%)