DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vimar and RAP1GDS1

DIOPT Version :9

Sequence 1:	NP_995767.1	Gene:	vimar / 35609	FlyBaseID:	FBgn0022960	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	NP_001093896.1	Gene:	RAP1GDS1 / 5910	HGNCID:	9859	Length:	608	Species:	Homo sapiens

Alignment Length:	630	Identity:	186/630 - (29%)
Similarity:	318/630 - (50%)	Gaps:	72/630 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IDDLIEKLKTTSVSPANTT-----NLLCEISATKDPKLFDKHE---LAECFLGLTKCDDTNVRKE 62
            :.|.::|||.|:|.....:     :.|.:..|..:.:..:|.:   :.:.|..|. ...::.:.:
Human     5 LSDTLKKLKITAVDKTEDSLEGCLDCLLQALAQNNTETSEKIQASGILQLFASLL-TPQSSCKAK 68

  Fly    63 AAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEARDLI 127
            .|..|||:.|:|..|.......:|:..::.|     :....|:.:|..||||||||.:.|.|..:
Human    69 VANIIAEVAKNEFMRIPCVDAGLISPLVQLL-----NSKDQEVLLQTGRALGNICYDSHEGRSAV 128

  Fly   128 LELEGDAVLL-RLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGIIDI 191
            .:..|..::: .|..:.:|.|.|| .:.:.|..|:|.||....:.|..:.:.:||:..|..::.|
Human   129 DQAGGAQIVIDHLRSLCSITDPAN-EKLLTVFCGMLMNYSNENDSLQAQLINMGVIPTLVKLLGI 192

  Fly   192 GASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNI--QLSRILAASTNPDLAEMCLELLHYQA 254
            ...|....|..|:    ....|.|..|.....:|.||  :|.::.......|..||..|:|...|
Human   193 HCQNAALTEMCLV----AFGNLAELESSKEQFASTNIAEELVKLFKKQIEHDKREMIFEVLAPLA 253

  Fly   255 ESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARALMKLACELIVLILTGDDSMHYLY---TTP 316
            |:|.:||.|.:.||.|.:..:::: |..:...:....:|...:|:||:|.||:||..|:   ...
Human   254 ENDAIKLQLVEAGLVECLLEIVQQ-KVDSDKEDDITELKTGSDLMVLLLLGDESMQKLFEGGKGS 317

  Fly   317 LLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKD-DVRLQH 380
            :.:.::.|:.|.:..|...|.||:.||||.|::||:.|:...:.||:::|.::  |:| :|.:||
Human   318 VFQRVLSWIPSNNHQLQLAGALAIANFARNDANCIHMVDNGIVEKLMDLLDRH--VEDGNVTVQH 380

  Fly   381 ALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALELLKNK 445
            |.|||||||.||..||..::.||:.:.:|..|:...|||.|||||||||.:|.|.:.|.:|.||.
Human   381 AALSALRNLAIPVINKAKMLSAGVTEAVLKFLKSEMPPVQFKLLGTLRMLIDAQAEAAEQLGKNV 445

  Fly   446 TLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQDYDR 510
            .|:|:||.|.::.|:|||.|||.||::.||:|:                              ..
Human   446 KLVERLVEWCEAKDHAGVMGESNRLLSALIRHS------------------------------KS 480

  Fly   511 SSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQA--------QLLQD 567
            ..:.:.:...|.::.:|:|.|::|::||||||:||.:::.:.|....:..::        :||.|
Human   481 KDVIKTIVQSGGIKHLVTMATSEHVIMQNEALVALALIAALELGTAEKDLESAKLVQILHRLLAD 545

  Fly   568 ELVKCEVGKKLAELIS--KSSDTMTKEIVENLQ--NCVNLLKSSE 608
            |....|:......||.  ..|:.:.|| |::|.  :.|:.|:|.|
Human   546 ERSAPEIKYNSMVLICALMGSECLHKE-VQDLAFLDVVSKLRSHE 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	ARM	55..155	CDD:237987	27/100 (27%)
		armadillo repeat	77..118	CDD:293788	11/40 (28%)
		armadillo repeat	124..165	CDD:293788	10/41 (24%)
		armadillo repeat	318..343	CDD:293788	6/24 (25%)
		ARM	322..428	CDD:237987	47/106 (44%)
		armadillo repeat	351..391	CDD:293788	18/40 (45%)
		armadillo repeat	396..428	CDD:293788	14/31 (45%)
RAP1GDS1	NP_001093896.1	ARM	44..167	CDD:237987	34/129 (26%)
		armadillo repeat	45..76	CDD:293788	6/31 (19%)
		armadillo repeat	92..117	CDD:293788	8/29 (28%)
		armadillo repeat	125..168	CDD:293788	12/43 (28%)
		ARM	141..232	CDD:237987	25/95 (26%)
		ARM	318..431	CDD:237987	50/114 (44%)
		armadillo repeat	352..391	CDD:293788	18/40 (45%)
		armadillo repeat	396..428	CDD:293788	14/31 (45%)
		ARM	440..>508	CDD:237987	25/97 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41422
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3398
Isobase	1	0.950	-	0	Normalized mean entropy	S5891
OMA	1	1.010	-	-		QHG52358
OrthoDB	1	1.010	-	-		D257055at33208
OrthoFinder	1	1.000	-	-		FOG0004617
OrthoInspector	1	1.000	-	-		oto90919
orthoMCL	1	0.900	-	-		OOG6_104598
Panther	1	1.100	-	-	O	PTHR10957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4845
SonicParanoid	1	1.000	-	-		X3822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.750