DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vimar and rap1gds1

DIOPT Version :9

Sequence 1:	NP_995767.1	Gene:	vimar / 35609	FlyBaseID:	FBgn0022960	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_002936785.2	Gene:	rap1gds1 / 100486041	XenbaseID:	XB-GENE-1004455	Length:	607	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	199/657 - (30%)
Similarity:	332/657 - (50%)	Gaps:	91/657 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IDDLIEKLKTTSVSPANTTNLL-----CEISA-----TKDPKLFDKHELAECFLGLTKCDDTNVR 60
            ::|.:||||.|...  .|::.|     |.:.|     |:..:...:..:.:.|..:.. .:::..
Frog     4 LNDALEKLKITGTE--CTSDKLDGCLDCLLQALGHNNTESSEKIQQSGILQLFASILN-SESSCS 65

  Fly    61 KEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDEARD 125
            .:.|..:|||.|:|:.|....:..:|...::.|.     ....|:.:|..||||||||.|.|.|.
Frog    66 SKVAHIVAEIAKNELMRIPCVEAGLIPPLVQLLH-----SKDQEVLLQTGRALGNICYDNHEGRR 125

  Fly   126 LILELEGDA--VLLRLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQGI 188
            .: :.||.|  |:..|..:.|:.| .::.:.:.|..|:|.||....:.|..:.:::||:..|..:
Frog   126 AV-DQEGGAQIVVDHLRSMCTLTD-PSSEKLMTVFCGMLMNYSSENDSLQTQLIQMGVIPILVDL 188

  Fly   189 IDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNI--QLSRILAASTNPDLAEMCLELLH 251
            :.:.:.|....|..|:    ....|.|..|.....:|.|:  ::.::....|..:..|:..|:|.
Frog   189 LGVHSQNTSLTEMCLV----AFGNLAELESSKEQFASTNVAEEIVKLFKKQTEHEKREIIFEVLA 249

  Fly   252 YQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEAR-ALMKLACELIVLILTGDDSMHYLY-- 313
            ..||:|.:|:.|.:.||.|.:.::::  :|:.|..:.. |.:|.:.:|:||:|.||:||..|:
Frog   250 PLAENDAIKMQLVEAGLVECLLDVVQ--QTVNSEKDDDIAELKTSSDLMVLLLLGDESMQKLFEG 312

  Fly   314 -TTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGVKD-DV 376
             ...:.:.::.||.|.:..|...|.||:.||||.|.:||:.|:...:.|||::|.::  |:| :|
Frog   313 GKGSVFQRVLSWLPSNNHQLQLAGALAIANFARNDGNCIHMVDSGIVQKLLDLLDRH--VEDGNV 375

  Fly   377 RLQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEKLALEL 441
            .:|||.|||||||.||..||..::.||:.:.:|..|....|||.|||||||||.:|.|.:.|.:|
Frog   376 TVQHAALSALRNLAIPVVNKAKMLSAGVAEEVLKFLRSEMPPVQFKLLGTLRMLIDAQAEAADQL 440

  Fly   442 LKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADKIPLTQ 506
            .||:.|:|:||.|.::.|:|||.|||.||::.||:|   ||                      ::
Frog   441 GKNEKLVERLVEWCEAKDHAGVMGESNRLLSALIRH---SK----------------------SK 480

  Fly   507 DYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQAQLLQDELVK 571
            |..|:     :...|.|:.:|:|.|::|::||||||:||.:::.:.|    :||:..|....||
Frog   481 DVIRT-----IVQSGGVKHLVTMATSEHVIMQNEALVALGLIAALEL----QAAEHDLESARLV- 535

  Fly   572 CEVGKKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQL------------VAHLEQHNINELLK 624
             ||..:|.     |.:....||..|....:..:..||.|            |:.|..|. |:.:.
Frog   536 -EVLHRLL-----SDERSAPEIKYNSMVLICAVMGSEPLHKEVQKLAFLDVVSKLRSHE-NKTVA 593

  Fly   625 SIPILTE 631
            ....|||
Frog   594 QQASLTE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	ARM	55..155	CDD:237987	29/101 (29%)
		armadillo repeat	77..118	CDD:293788	11/40 (28%)
		armadillo repeat	124..165	CDD:293788	11/42 (26%)
		armadillo repeat	318..343	CDD:293788	7/24 (29%)
		ARM	322..428	CDD:237987	49/106 (46%)
		armadillo repeat	351..391	CDD:293788	19/40 (48%)
		armadillo repeat	396..428	CDD:293788	14/31 (45%)
rap1gds1	XP_002936785.2	armadillo repeat	44..71	CDD:293788	2/27 (7%)
		PLN03200	53..>190	CDD:215629	39/144 (27%)
		ARM	78..118	CDD:214547	12/44 (27%)
		armadillo repeat	91..116	CDD:293788	8/29 (28%)
		armadillo repeat	124..167	CDD:293788	13/44 (30%)
		ARM	169..210	CDD:214547	7/44 (16%)
		Vitellogenin_N	<220..415	CDD:391646	67/198 (34%)
		armadillo repeat	319..343	CDD:293788	7/23 (30%)
		ARM	346..389	CDD:214547	20/44 (45%)
		armadillo repeat	351..390	CDD:293788	19/40 (48%)
		armadillo repeat	395..427	CDD:293788	14/31 (45%)
		Arm	479..518	CDD:366143	16/43 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41422
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3332
OMA	1	1.010	-	-		QHG52358
OrthoDB	1	1.010	-	-		D257055at33208
OrthoFinder	1	1.000	-	-		FOG0004617
OrthoInspector	1	1.000	-	-		otm49052
Panther	1	1.100	-	-	O	PTHR10957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080