DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vimar and rap1gds1

DIOPT Version :9

Sequence 1:	NP_995767.1	Gene:	vimar / 35609	FlyBaseID:	FBgn0022960	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_021333729.1	Gene:	rap1gds1 / 100334870	ZFINID:	ZDB-GENE-101230-2	Length:	607	Species:	Danio rerio

Alignment Length:	662	Identity:	193/662 - (29%)
Similarity:	314/662 - (47%)	Gaps:	101/662 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DDLIEKLKTTSVSPANTTN-----LLCEISATKDPKLFDKHELAECFLGL-----------TKCD 55
            |:|.|.|||..:|.|..::     |.|.:.|.....:....::.|  :|:           ..|
Zfish     3 DNLSEALKTLKLSSAGASDSVEGCLDCLLKALAHNNVETSEKIQE--MGVLASMPALLSVQNSC- 64

  Fly    56 DTNVRKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLN 120
                ..:.|..|||:.|:|..|....:..:|...::.|     :....|:.:|..||||||||.:
Zfish    65 ----TSKVANIIAEVAKNEFMRSPCVEAGLIPPLVQLL-----NSKDQEILLQTGRALGNICYDS 120

  Fly   121 DEARDLILELEGDAVLL--RLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMK 183
            .|.|..: :..|.|.::  .:..:....|.| ..:.:.|..|:|.||....:.|..:.:.:||:.
Zfish   121 HEGRSAV-DAAGGAQIVTEHIKSLAESTDPA-TGKLLTVFCGMLMNYSNDNDSLQAQLISMGVIP 183

  Fly   184 KLQGIIDIGASNVEQHEDLLLNTLPLLSILTENVSDLNFDSSLNI--QLSRILAASTNPDLAEMC 246
            .|..::.:.:.|....|..|:    ....|.|..|.....:|.||  :|.|:.......:..||.
Zfish   184 TLVRLLGVHSQNTPLTEMCLI----AFGNLAELESSKEQFASTNIAEELVRLFRKQAEHEKKEMI 244

  Fly   247 LELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLAS-TSEARALMKLACELIVLILTGDDSMH 310
            .|:|...||:|.:||.|...||.|.:..::.  :|:.| ..|..|.:|.|.:|:||:|.||:||.
Zfish   245 FEVLAPLAENDVIKLQLVDAGLVECLLEVVA--QTVNSEREEDAAQLKTASDLMVLLLLGDESMQ 307

  Fly   311 YLY---TTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKNNGV 372
            .|:   ...:.:.::.|:.|.:..|...|.||:.||||.|.:||:.|:...:.||||:|.::  |
Zfish   308 KLFEGGKGSVFQRVLSWVPSNNHQLQLAGALAIANFARNDGNCIHMVDTGIVQKLLELLDRH--V 370

  Fly   373 KD-DVRLQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQEK 436
            :: :|.:|||.|||||||.||..||:.::.||:...:|..|:...|||.|||||||||.:|.|..
Zfish   371 EEGNVTVQHAALSALRNLAIPVVNKSKMLLAGVSDVVLKFLKSEMPPVQFKLLGTLRMLIDTQAD 435

  Fly   437 LALELLKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIADK 501
            .|.:|..|..|:|:||.|.::.|:|||.|||.||::.||:|:...::.
Zfish   436 AAEQLGTNVKLVERLVEWCEAKDHAGVMGESNRLLSALIRHSKSKEVV----------------- 483

  Fly   502 IPLTQDYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQAQLLQ 566
                         ..:...|.|:.:|.|.|::|::||||||:||.:::.::|    :.|:...:.
Zfish   484 -------------RTVIQGGGVKHLVLMATSEHMIMQNEALVALGLIAALHL----DCAEKDFVS 531

  Fly   567 DELVKCEVGKKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQL------------VAHLEQHNI 619
            ..||..     |.:|:::  :....||..|....:..:..||.|            |:.|..|.
Zfish   532 SSLVTV-----LHKLLTE--EHSAPEIKYNSMILICSIMGSEPLHKEVQSLAFIDVVSGLRSHE- 588

  Fly   620 NELLKSIPILTE 631
            |:.:.....|||
Zfish   589 NKTVSHQASLTE 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	ARM	55..155	CDD:237987	25/101 (25%)
		armadillo repeat	77..118	CDD:293788	11/40 (28%)
		armadillo repeat	124..165	CDD:293788	8/42 (19%)
		armadillo repeat	318..343	CDD:293788	6/24 (25%)
		ARM	322..428	CDD:237987	48/106 (45%)
		armadillo repeat	351..391	CDD:293788	19/40 (48%)
		armadillo repeat	396..428	CDD:293788	14/31 (45%)
rap1gds1	XP_021333729.1	PLN03200	<41..>151	CDD:331927	28/123 (23%)
		armadillo repeat	44..71	CDD:293788	4/33 (12%)
		Arm	86..117	CDD:278915	9/35 (26%)
		armadillo repeat	91..116	CDD:293788	8/29 (28%)
		armadillo repeat	124..167	CDD:293788	10/44 (23%)
		ARM	346..389	CDD:214547	20/44 (45%)
		armadillo repeat	351..390	CDD:293788	19/40 (48%)
		armadillo repeat	395..427	CDD:293788	14/31 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4500
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41422
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3963
OMA	1	1.010	-	-		QHG52358
OrthoDB	1	1.010	-	-		D257055at33208
OrthoFinder	1	1.000	-	-		FOG0004617
OrthoInspector	1	1.000	-	-		otm26259
orthoMCL	1	0.900	-	-		OOG6_104598
Panther	1	1.100	-	-	O	PTHR10957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4845
SonicParanoid	1	1.000	-	-		X3822
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800