DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vimar and si:dkey-191g9.5

DIOPT Version :9

Sequence 1:	NP_995767.1	Gene:	vimar / 35609	FlyBaseID:	FBgn0022960	Length:	635	Species:	Drosophila melanogaster
Sequence 2:	XP_001921954.3	Gene:	si:dkey-191g9.5 / 100148873	ZFINID:	ZDB-GENE-090313-217	Length:	560	Species:	Danio rerio

Alignment Length:	669	Identity:	183/669 - (27%)
Similarity:	299/669 - (44%)	Gaps:	153/669 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AEIDDLIEKLKTTSVSPANT-----------TNLLCEISATKDPKLFDKHELAECFLGLTKCDDT 57
            |:|:.|.|.||..|||....           .|||.|.......|:.....|......|.|  .:
Zfish     2 ADIESLSEALKGISVSTELVEEELKPHLDVLLNLLLEKKKGTAEKIVSSGVLPILTQVLRK--KS 64

  Fly    58 NVRKEAAKCIAEITKSEVQRKKFTKRNIIAAFLECLRQVPTSDGSMELPIQICRALGNICYLNDE 122
            .:..:....:||:.:....|:...:..::.|.:..|:. |..|..:...    ||:|.||:
Zfish    65 PLTSQVTLLVAEMAREATVREHCIEAGLVTALVPLLKS-PDQDQLLHTG----RAIGRICF---- 120

  Fly   123 ARDLILELEGDAVLLRLLDITTIEDVANAAQFIKVRGGLLSNYLLGGEGLAKRAMELGVMKKLQG 187
                                      .||.|                   ..:.:|.||:.:|..
Zfish   121 --------------------------ENAVQ-------------------QTQLVENGVIPRLVA 140

  Fly   188 IIDIGASNVEQHEDLLLNTLPLLSILT--------ENVSDLNFDSSLNIQLSRILAASTNPDLAE 244
            |:.....|     |.|:|.. ||::..        |.:::::....|..||.|    :.:.:...
Zfish   141 IMQQYPEN-----DPLVNVC-LLALCNLADVDAAREALTEVDVAEVLTHQLKR----APDAERRH 195

  Fly   245 MCLELLHYQAESDEVKLILAKDGLCETIYNLLEKYKTLASTSEARAL--MKLACELIVLILTGDD 307
            :.||:|....|||.:||...:.|:.|.   |.|..:||...|:...|  :|:|..|||.:|.||:
Zfish   196 LILEVLGSLGESDALKLQFVESGVPEA---LSEMIRTLQGGSDTHDLCSIKVASNLIVTLLLGDE 257

  Fly   308 SMHYLY---TTPLLKNMVDWLDSTDIDLLTTGVLALGNFARTDSHCIYFVEQQTMNKLLEVLAKN 369
            ||...:   |..:.::::.||.|::.:|..:|.||:.||||.||:|:..:|...:.::|::| :.
Zfish   258 SMQKCFGEGTGMVYQDVLAWLQSSNTELQLSGALAIANFARNDSNCVKMLELGVVPRILDLL-EQ 321

  Fly   370 NGVKDDVRLQHALLSALRNLVIPKPNKNAVIQAGLVQTILPMLEIHQPPVVFKLLGTLRMTVDGQ 434
            :..:.||.:|||.|||||||.||..||..:::.|:.:.|..:|....|||.|||||||||.||||
Zfish   322 HVAEGDVSVQHAGLSALRNLAIPASNKVRMLEDGVTERIRKLLCSDMPPVQFKLLGTLRMMVDGQ 386

  Fly   435 EKLALELLKNKTLIEQLVHWSKSSDYAGVTGESLRLMAWLIKHAYLSKIAYALPRKGDAPAEQIA 499
            |:.|..|.|::.|:.:::.|.::.|:|||.||:.||:|.||:|:...::.:.: .|.|.
Zfish   387 EEAASVLGKDEALLARVMEWCEAKDHAGVRGEANRLLAALIRHSRNPEVIHTV-IKADG------ 444

  Fly   500 DKIPLTQDYDRSSLSEFLANEGTVEAMVSMLTAQHLVMQNEALIALCILSVVYLSQPSEAAQ--- 561
                                   |:.::||.|::|::||||||:||.|.|.:.:    ||.|
Zfish   445 -----------------------VQHLISMATSEHVIMQNEALVALAIASAIDI----EAVQEPF 482

  Fly   562 ---------AQLLQDELVKCEVG-KKLAELISKSSDTMTKEIVENLQNCVNLLKSSEQLVAHLEQ 616
                     .::|.|..|..||. ..|..:.|..:.|:.:|.:.:|    ||    ...::.|..
Zfish   483 RDADLLPTLQKMLDDPDVAVEVKFSALGLICSLVNSTILREQITSL----NL----RDTLSKLSN 539

  Fly   617 HNINELLKS----IPILTE 631
            |...:|.|.    :.:|:|
Zfish   540 HTSTKLAKQADTVMAVLSE 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vimar	NP_995767.1	ARM	55..155	CDD:237987	15/99 (15%)
		armadillo repeat	77..118	CDD:293788	9/40 (23%)
		armadillo repeat	124..165	CDD:293788	3/40 (8%)
		armadillo repeat	318..343	CDD:293788	7/24 (29%)
		ARM	322..428	CDD:237987	45/105 (43%)
		armadillo repeat	351..391	CDD:293788	15/39 (38%)
		armadillo repeat	396..428	CDD:293788	13/31 (42%)
si:dkey-191g9.5	XP_001921954.3	ARM	45..163	CDD:237987	30/179 (17%)
		armadillo repeat	88..118	CDD:293788	7/34 (21%)
		armadillo repeat	126..163	CDD:293788	11/42 (26%)
		ARM	274..383	CDD:237987	48/109 (44%)
		armadillo repeat	304..343	CDD:293788	15/39 (38%)
		armadillo repeat	349..380	CDD:293788	12/30 (40%)
		ARM	439..558	CDD:237987	37/160 (23%)
		armadillo repeat	439..470	CDD:293788	15/60 (25%)
		armadillo repeat	478..516	CDD:293788	8/37 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595896
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4500
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3963
OMA	1	1.010	-	-		QHG52358
OrthoDB	1	1.010	-	-		D257055at33208
OrthoFinder	1	1.000	-	-		FOG0004617
OrthoInspector	1	1.000	-	-		otm26259
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4845
SonicParanoid	1	1.000	-	-		X3822
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.900