Protein Alignment Cyp6u1 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_610252.3
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 123/520 - (23%)
• Similarity: 210/520 - (40%)
• Gaps: 67/520 - (12%)

  Fly     8 LLTALGALSVVYALVKFSLGYW---KRRGILHEKPK--FLWGNIKGVVSGKRHAQDALQDIYTAY 67
            ||..:||..::..::.::..::   :|.....:.|:  :.||: :|:|:........|..:...|
Human    21 LLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGH-QGMVNPTEEGMRVLTQLVATY 84

  Fly    68 KGRAPFVGFYACLKPFILALDL---KLVHQIIFTDAGHFTSRGLYSNPSGEP-LSHNLLQLDGHK 128
            .     .||...:.|....|.|   .::..:|...|. ...:..:.....|| |...||...|.|
Human    85 P-----QGFKVWMGPISPLLSLCHPDIIRSVINASAA-IAPKDKFFYSFLEPWLGDGLLLSAGDK 143

  Fly   129 WRSLHAKSAEVFTPA---NMQKLLVRLSQISSRIQRD----LGEKSLQTINISELVGAYNTDVMA 186
            | |.|.:   :.|||   |:.|..:::...|..|...    |..:....:::.|.:.....|.:.
Human   144 W-SRHRR---MLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQ 204

  Fly   187 SMAFGLVGQDNVEFAKWTRNYWADFRMWQAYLALEFPLIARLLQYKSYAEPATAYFQKVA----- 246
            ...|..    :....:....|.|......|.::.....|...:.:..|..|....|::..
Human   205 KCVFSF----DSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHD 265

  Fly   247 LSQLQLHRRRDRQPLQ---TFLQ--------------LYSNAE--KPLTDIEIAGQAFGFVLAGL 292
            .:...:..||...|.|   .|||              |.|..|  |.|:|.:|..:|..|:..|.
Human   266 FTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGH 330

  Fly   293 GPLNATLAFCLYELARQPEVQDRTRLEINKALEE-HGGQVTPECLRELRYTKQVLNETLRLHTPH 356
            ....:.|::.||.||:.||.|:|.|.|:.:.|:: ...::..:.|..|.:....:.|:||||.|.
Human   331 DTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPV 395

  Fly   357 PFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFL 421
            |.:.|..|::..:|.. .||.||...||.....|.:|.::.:|:.:.|.||:.:..:.|...||:
Human   396 PVISRHVTQDIVLPDG-RVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFI 459

  Fly   422 PFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRR---LLLMPKSDIKLSVE 483
            ||..|.|.||...||..::.|.|...|.:.|.       :|...:.||   |:|..:..:.|.||
Human   460 PFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV-------LPDHTEPRRKPELVLRAEGGLWLRVE 517

  Fly   484  483
            Human   518  517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_610252.3	CYP6-like	69..479	CDD:410679	108/448 (24%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	110/462 (24%)