Protein Alignment Cyp6u1 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_610252.3
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 147/589 - (24%)
• Similarity: 245/589 - (41%)
• Gaps: 151/589 - (25%)

  Fly    14 ALSV-VYALVKF----SLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRAPF 73
            |||| :.||:|:    :....::.|:.|.||....||:.....|...:|..|:.:|      .|.
Human    19 ALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLY------GPL 77

  Fly    74 VGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKWRSLHAKSAE 138
            .|:|...:.||:..:..::.|::..:..:||:| :.|....:.::.::|.|...:|..:......
Human    78 CGYYLGRRMFIVISEPDMIKQVLVENFSNFTNR-MASGLEFKSVADSVLFLRDKRWEEVRGALMS 141

  Fly   139 VFTPANMQKLLVRLSQISSRIQRDLG--------------------------------------- 164
            .|:|..:.:|.:.:.|  .||:..:|
Human   142 AFSPEKLNELGLLIMQ--ERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVPLISQA 204

  Fly   165 -----------EKSLQTINISELVGAYNTDVMASMAFGL------VGQDNVEFAKWTRNYWADFR 212
                       .:|....:|......|.|||:||:|||.      ..:|  .|.|..:.:: :|.
Human   205 CDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPED--PFVKHCKRFF-EFC 266

  Fly   213 MWQAYLA--LEFPLI----ARLLQYKSYAEPATAYFQK-----VALSQLQL--HRRRDRQPLQTF 264
            :.:..|.  |.||.|    ||:|..|:..| ...:|.|     :||...|.  .||||      |
Human   267 IPRPILVLLLSFPSIMVPLARILPNKNRDE-LNGFFNKLIRNVIALRDQQAAEERRRD------F 324

  Fly   265 LQLYSNAE-------------------------------------KPLTDIEIAGQAFGFVLAGL 292
            ||:..:|.                                     :|||..||.||||.|::||.
Human   325 LQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGY 389

  Fly   293 GPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPE-CLRE--LRYTKQVLNETLRLHT 354
            ..:..||:|..|.||..|:.|::...|::...|:|   :.|| |..|  |.|...|:.||||::.
Human   390 EIITNTLSFATYLLATNPDCQEKLLREVDVFKEKH---MAPEFCSLEEGLPYLDMVIAETLRMYP 451

  Fly   355 PHPFLLRRATKEFEV------PGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARR 413
            |.....|.|.::.||      .|:|..:|.|        |:|.||..:.:|:.|.||||..:||:
Human   452 PAFRFTREAAQDCEVLGQRIPAGAVLEMAVG--------ALHHDPEHWPSPETFNPERFTAEARQ 508

  Fly   414 SRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDI 478
            ......:||||.|.|.|:..|....::.:.|:.:|.:.|:....||.:|::.:::. .|.||:.:
Human   509 QHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGV 572

  Fly   479 KLSV 482
            .:.:
Human   573 YIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_610252.3	CYP6-like	69..479	CDD:410679	130/524 (25%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	131/530 (25%)