Protein Alignment Cyp6u1 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_610252.3
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 113/481 - (23%)
• Similarity: 194/481 - (40%)
• Gaps: 54/481 - (11%)

  Fly    38 KPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGH 102
            |..:.||::..:...:...:::.|...|..:|   |..:...:.|||:......:..|....|..
Human    56 KRNWFWGHLGLITPTEEGLKNSTQMSATYSQG---FTVWLGPIIPFIVLCHPDTIRSITNASAAI 117

  Fly   103 FTSRGLYSNPSGEPLSHNLLQLDGHKWRSLHAKSAEVFTPA---NMQKLLVRLSQISSRIQRD-- 162
            .....|:.......|...:|...|.|| |.|.:   :.|||   |:.|..:.:...|:.|..|
Human   118 APKDNLFIRFLKPWLGEGILLSGGDKW-SRHRR---MLTPAFHFNILKSYITIFNKSANIMLDKW 178

  Fly   163 --LGEKSLQTINISELVGAYNTDVMASMAFGLVGQDNVEFAKWTRNYWADFRMWQAYLALEFPLI 225
              |..:....:::.|.:.....|.:....|..    :....:....|.|......|.:......|
Human   179 QHLASEGSSRLDMFEHISLMTLDSLQKCIFSF----DSHCQERPSEYIATILELSALVEKRSQHI 239

  Fly   226 ARLLQYKSYAEPATAYFQKVA-----LSQLQLHRRRDRQPLQ---------------TFLQ--LY 268
            .:.:.:..|.......|.:..     .:...:..||...|.|               .|:.  |.
Human   240 LQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLLL 304

  Fly   269 SNAE--KPLTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHG-GQ 330
            |..|  |.|:|.:|..:|..|:..|.....:.|::.||.|||.||.|:|.|.|:.:.|::.. .:
Human   305 SKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKE 369

  Fly   331 VTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGI 395
            :..:.|.:|.:....:.|:||||.|.||:.|..|::..:|.. .||.||...||....:|.:|.:
Human   370 IEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDG-RVIPKGITCLIDIIGVHHNPTV 433

  Fly   396 YENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETS 460
            :.:|:.:.|.||:.:..:.|...||:||..|.|.||...||..::.|.|..:|...|:
Human   434 WPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRF------- 491

  Fly   461 IPVEYDNRR---LLLMPKSDIKLSVE 483
            :|...:.||   |::..:..:.|.||
Human   492 LPDHTEPRRKLELIMRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_610252.3	CYP6-like	69..479	CDD:410679	105/444 (24%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	107/459 (23%)