DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	516	Identity:	135/516 - (26%)
Similarity:	238/516 - (46%)	Gaps:	48/516 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDL-----MHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNI----KGVVSGKRHA 56
            |||     |...:|.|. :|.::|.....|...:|:.||....|....|.|    :|:.:..|..
Human     1 MDLIPNFAMETWVLVAT-SLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNFDREC 64

  Fly    57 QDALQDIYTAYKGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNL 121
            .:...:::..|:|:          :|.::.:|..::..::..:.....:..:...|.|. |...|
Human    65 NEKYGEMWGLYEGQ----------QPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGF-LKSAL 118

  Fly   122 LQLDGHKWRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGE--KSLQTINISELVGAYNTDV 184
            ...:..:|:.:....:..||....::::..:||....:.|.|.:  ::.::||:.:..|||..||
Human   119 SFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDV 183

  Fly   185 MASMAFGLVGQDNVE-----FAKWTRNYW-ADFRMWQAYLALEFPLIA---RLLQYKSYAEPATA 240
            :....|| |..|::.     |.|..:... .||......|...||.:.   ..|....:.:..|
Human   184 ITGTLFG-VNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVT- 246

  Fly   241 YFQKVALSQLQLHRRRDRQP--LQTFLQLY-------SNAEKPLTDIEIAGQAFGFVLAGLGPLN 296
            :|.|.::.:::..|.:|:|.  :..|.|:.       :.:.|.|:|:|:..|:...:.|.....:
Human   247 HFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTS 311

  Fly   297 ATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLR 361
            .||.|.:||||..|:||.:.:.||:..| .:...||.:.|.::.|...|:||||||......:.|
Human   312 TTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTR 375

  Fly   362 RATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPE-RFEEQARRSRPAAAFLPFGD 425
            ...|:.|:.| || |.||..|::|..|:|.||..:..|::|.|| ||.::.:.|.....::|||.
Human   376 VCKKDIEING-VF-IPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGA 438

  Fly   426 GLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERVD 486
            |.|.||..|||...:.:.::..|:...:.|..||.||::.||.. :|.|:..|.|.|...|
Human   439 GPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP-ILQPEKPIVLKVHLRD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	118/461 (26%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	121/471 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820