DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6u1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	515	Identity:	142/515 - (27%)
Similarity:	228/515 - (44%)	Gaps:	61/515 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRA 71
            |||..|.||.|:|.  .:...|:|:.||...|....:|.:.....| .|..|  .|.:..| ||
Zfish     9 TLLAFLAALLVIYG--SWPHRYFKKLGIPGPKAIPFFGTMLRYKDG-FHVFD--MDCFEKY-GR- 66

  Fly    72 PFVGFYACLKPFILALDLKLVHQI-------IFTDAGHFTSRG-LYSNPSGEPLSHNLLQLDGHK 128
             ..|.|...:|.:..:|..::..:       :||:..:|...| ||...|         ..:...
Zfish    67 -IWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRRNFRLNGALYDAVS---------IAEDDD 121

  Fly   129 WRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGE--KSLQTINISELVGAYNTDVMASMAFG 191
            ||.:.:..:..||...::::...:.:.|..:...:|:  |..::.:|.|..|||:.||:.|.||.
Zfish   122 WRRIRSVLSPSFTSGRLKEMFGIMKKHSHILVDSMGKTAKRGESADIKEFFGAYSMDVVTSTAFS 186

  Fly   192 LVGQDNVEFAK--WTRNY--WADFRMWQAYLAL--EFPLIARLLQYKSYA---EPATAYFQKVAL 247
             |..|::...|  :..|.  ...|.:......|  .||.:|.:|:...:|   ...|.:|. .||
Zfish   187 -VDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTDFFY-AAL 249

  Fly   248 SQLQLHR------RRDRQPLQTFLQLY-------------SNAEKPLTDIEIAGQAFGFVLAGLG 293
            .:::..|      :.:.:....||||.             .:.||.|:|.||..|:..|:.||..
Zfish   250 QKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMIFIFAGYE 314

  Fly   294 PLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPF 358
            ..::||:|..|.||..||...:.:.||::..... ..|..|.|..:.|....|:|:|||......
Zfish   315 TSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQ-APVDYETLMSMDYLDAALSESLRLFPVAAR 378

  Fly   359 LLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPF 423
            |.|...|..|:.|  .:|.|...|::||.|:|.||..:..|:.|.||||.:..:.|.....::||
Zfish   379 LERVCKKTVEING--LLIPKDLVVMVPTYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPF 441

  Fly   424 GDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVE 483
            |.|.|.||..|||:..:.:.:|.:|::...:...||.:|:|..... ||.||..|||.::
Zfish   442 GLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPLELGFNG-LLSPKDPIKLKLQ 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	125/474 (26%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	130/484 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920