Protein Alignment Cyp6u1 and cyp3a4.2

DIOPT Version :10

• Sequence 1: NP_610252.3
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_001015786.1
• Gene: cyp3a4.2 / 548503
• XenbaseID: XB-GENE-971750
• Length: 504
• Species: Xenopus tropicalis
• Alignment Length: 512
• Identity: 137/512 - (26%)
• Similarity: 215/512 - (41%)
• Gaps: 70/512 - (13%)

  Fly     8 LLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNI----KGVVSGKRHAQDALQDIYTAYK 68
            ||.||..|.::|.:  :..||:|:.||....|....|..    ||:|............::..|.
 Frog    14 LLAALLVLILLYGI--WPYGYFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYD 76

  Fly    69 GRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKWRSLH 133
            ||.|.:   |.:.|.|:...|.......||:..:|...|        |....:...:..:|:.:.
 Frog    77 GRQPVL---AIMDPAIIKTILVKECYTNFTNRRNFGLNG--------PFESAITIAEDEQWKRIR 130

  Fly   134 AKSAEVFTPANMQKLL--------VRLSQISSRIQRDLGEKSLQTINISELVGAYNTDVMASMAF 190
            ...:..||...::::.        :.:..|...:::|      :.....:::|||:.||:.|.:|
 Frog   131 NVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYVEKD------EPCATKDVIGAYSMDVITSTSF 189

  Fly   191 GLVGQDNVEFAKWTRNYWAD---FRMWQ----------AYLALEFPLIARLLQ---YKSYAEPAT 239
            .:    |::    :.|..:|   ..|.:          ..|.:.||.:..:|:   .....:..|
 Frog   190 SV----NID----SLNKPSDPFVIHMKKLLKTGLLSPLLILVVIFPFLRPILEGLNLNFVPKDFT 246

  Fly   240 AYFQKVALSQLQLHRRRDRQPLQTFLQL-----------YSNAEKPLTDIEIAGQAFGFVLAGLG 293
            .:|.....|..:..::.|.......|||           .||..|.|||.||..|:..|::||..
 Frog   247 EFFMNAVTSFREKRKKGDHSGRVDLLQLMMDSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYE 311

  Fly   294 PLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPF 358
            ..:..|::..|.||..|:||.|...||:..|.:.... |.:.|.::.|...|:.|||||..|...
 Frog   312 TTSTALSYLFYNLATHPDVQQRLHEEIDSFLPDKASP-TYDILMQMEYLDMVIQETLRLFPPAGR 375

  Fly   359 LLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPF 423
            |.|.:.:..|:.|  ..|.||...|||...:..||..:..|:.|.||||.::.|.:.....||||
 Frog   376 LERVSKQNVEING--VSIPKGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPF 438

  Fly   424 GDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKL 480
            |||.|.||..|||...:.|.:|.||:.....|.|||.||:|:.... .|.||..|.|
 Frog   439 GDGPRNCIGLRFALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIG-FLQPKKPIVL 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_610252.3	CYP6-like	69..479	CDD:410679	118/444 (27%)
cyp3a4.2	NP_001015786.1	CYP3A	67..495	CDD:410743	121/457 (26%)