DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	140/521 - (26%)
Similarity:	230/521 - (44%)	Gaps:	66/521 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLMHRTLLTALGALSVVYAL-VKFSL---GYWKRRGILHEKPKFLWGNIKGVVSG--KRHAQDA 59
            |||:....|.....|:::..| .:|..   |.:|::||...||....|.:.....|  |...:
  Rat     1 MDLVSALSLETWLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVLNYYRGLWKFDME-- 63

  Fly    60 LQDIYTAYKGRAPFVGFYACLKPFILALDLKLVHQI-------IFTDAGHFTSRGLYSNPSGEPL 117
                  .||......|.:....|....:|.:::..:       :||:..:....|:        :
  Rat    64 ------CYKKCGKIWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNIGPVGI--------M 114

  Fly   118 SHNLLQLDGHKWRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEK--SLQTINISELVGAY 180
            |.::......:|:...|..:..||...::::...:......:.:.|.:|  ..:.:.:.|:.|||
  Rat   115 SKSISVAKDEEWKRYRAFLSPTFTSGRLKEMFPIIEHYGDILVKYLKQKVEKGKPLAMKEVFGAY 179

  Fly   181 NTDVMASMAFGL-VGQDN------VEFAKWTRNYWADFRMWQAYLALEFPL---IARLLQYKSYA 235
            :.||:.|.:|.: :...|      ||..|..:.:  ||........:.||.   |..:|....:.
  Rat   180 SMDVITSTSFEVNINSINNPKDPFVEKVKKFQRF--DFFDPLFLSVVLFPFLTPIYEMLNICLFP 242

  Fly   236 EPATAYFQKVA--LSQLQL---HRRRDRQPLQTFLQLYSNA---------EKPLTDIEIAGQAFG 286
            :.:.|:|||..  :.|.:|   |:.|     ..||||..||         .|.|:||||..||..
  Rat   243 KDSVAFFQKFVYRMKQTRLDSKHKHR-----VDFLQLMMNAHNNSKDKVSHKALSDIEIVAQAII 302

  Fly   287 FVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLR 351
            |:.|.....::||:|.||.||..|:.|.:.:.||::|| .:....|.:.:.|:.|...|||||.|
  Rat   303 FIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETPR 366

  Fly   352 LHTPHPFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRP 416
            |: |..:.|.|..|:......|| |.||:.|:||...:..||..:..|:.|.||||.::.:.|..
  Rat   367 LY-PIGYRLERVCKKDIKLDGVF-IPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSID 429

  Fly   417 AAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLS 481
            ...:||||:|.|.||..|||...:.:.|..:|:...:....||.||::...:| |..|:..|.|.
  Rat   430 PYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQR-LFGPEKPIVLK 493

  Fly   482 V 482
            |
  Rat   494 V 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	125/471 (27%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	120/444 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010