DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	521	Identity:	134/521 - (25%)
Similarity:	229/521 - (43%)	Gaps:	78/521 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LGALSVVYALVKFSL-----------GYWKRRGILHEKPKFLWGNIKGVVSG---------KRHA 56
            |.:|||.:.||...:           |::|:.||...:|...:|.......|         |::.
Zfish     4 LSSLSVTWTLVFLVITLLYMYGVWPHGFFKKLGIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYG 68

  Fly    57 QDALQDIYTAYKGRAPFVGFYACLKPFILALDLKLVHQIIFTDA-GHFTSRGLYSNPSGEPLSHN 120
            :     ::..|.||.          |.::..||:::..|:..:. ..||:|...:.....||:..
Zfish    69 K-----VWGIYDGRL----------PILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADG 118

  Fly   121 LLQLDGHKWRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEKS-LQTINISELVGAYNTDV 184
            :..:...:|:.:....:..||...::::.......:.|..:::.::. .|.:.|.|:|..|:.||
Zfish   119 ISAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQPVKIKEVVAPYSLDV 183

  Fly   185 MASMAFGL----VGQDNVEFAKWTRNY--WADFRMWQAYLALEFPLIARLLQYK--SYAEPATAY 241
            :.|.:|.:    :...:..|....:|:  ::.|.....:|.| ||.||.||...  |....:...
Zfish   184 VTSSSFSVDIDSINNPDDPFVTNIKNFLKFSLFSPLILFLTL-FPSIANLLGKMGISVFSRSIMN 247

  Fly   242 FQKVALSQLQLHRRRDRQPLQTFLQLY------------SNAEKP---LTDIEIAGQAFGFVLAG 291
            |...||.::: ...:|......||:|.            :.:|:|   |||.||..|:|.|:|.|
Zfish   248 FFYTALRKIK-DEHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGG 311

  Fly   292 LGPLNATLAFCLYELARQPEVQDRTRLEINK--ALEEHGGQVTP---ECLRELRYTKQVLNETLR 351
            ....:.||:|.|:.||..|:..::...||:|  .|:      ||   :.|.::.|.:..:||::|
Zfish   312 YETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLD------TPISYDALMKMDYLEMSINESMR 370

  Fly   352 LHTPHPFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRP 416
            |....|.|.|...|..|:.|  ..|.|...|.|||..::.||.::::||.|.||||..:.:....
Zfish   371 LLPTAPRLERVCKKTVELNG--ITIPKDTLVAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFL 433

  Fly   417 AAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLS 481
            ..||:|||.|.|.||..|||...:.:.:|.||:........||.||:|...   :..||..|.|.
Zfish   434 QYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQIPLELTP---VFQPKVPITLK 495

  Fly   482 V 482
            :
Zfish   496 L 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	120/475 (25%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	124/485 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820