DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6u1 and Cyp6d4

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	532	Identity:	149/532 - (28%)
Similarity:	253/532 - (47%)	Gaps:	65/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFL-WGNIKGVVSGKRHAQDALQDIYTAY 67
            |...:|.|:..|::.:..:|....||:|||...||...: :|.:..|...::....|:.|:|...
  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKS 65

  Fly    68 KGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKWRSL 132
            |.|.  :|.|...:|.:|..|..|..:::..|...|..||:|.:...:|||.|:..|.|..|||:
  Fly    66 KERV--LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWRSM 128

  Fly   133 HAKSAEVFTPANMQKLLVRLSQISSR----IQRDLGEKSLQTINISELVGAYNTDVMASMAFGL- 192
            ....:..||...::.:......|..:    :|::|.|:..:.::|.:::..|..|::||..|||
  Fly   129 RHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLD 193

  Fly   193 ----VGQDN-----VEFAKWTRNYWADFRMWQAYLALEFPLIARLLQYKSYAEPATAYFQKVALS 248
                ...||     |..|:....:.|.|.|    :....|.||:.|....:..|       |.|:
  Fly   194 VNSFENPDNKFRKLVSLARANNRFNAMFGM----MIFLVPSIAQFLFRIGFKNP-------VGLA 247

  Fly   249 QLQLHR------------RRDRQPLQTFLQLYS------NAEKPLT------------DIE-IAG 282
            .||:.:            |:|.  ||..:||.:      |.||..:            .:| |..
  Fly   248 MLQIVKETVEYREKHGIVRKDL--LQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITA 310

  Fly   283 QAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLN 347
            |||.|.:||.....:|.||.:||||:.||:..|.:.|:::.|.::.|::|.:.|.::.:....:.
  Fly   311 QAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQ 375

  Fly   348 ETLRLHTPHPFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQAR 412
            ||:|.:...|.|.|..|:::.||.:..||.||..|:|....||.|...:.:|:.:.||||.|::|
  Fly   376 ETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESR 440

  Fly   413 RSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSD 477
            ...| .||:|||:|.|.|||.|.......:.::.:|:.......:.:.|  |::|..:.|:||..
  Fly   441 NYNP-TAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIALIPKHG 502

  Fly   478 IKLSV-ERVDKL 488
            :::.: :||.||
  Fly   503 VRVRLSKRVPKL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	132/482 (27%)
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	128/459 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461194
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	180	1.000	Inparanoid score	I2666
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900