DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	517	Identity:	135/517 - (26%)
Similarity:	243/517 - (47%)	Gaps:	59/517 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRAPFVGFYA 78
            |.::.|.....:..::|.|||.:|||...:||:.|:...||...|.:.|:||. .|...|.|.:.
  Fly    12 AAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTK-GGSKKFFGIFE 75

  Fly    79 CLKPFILALDLKLVHQIIFTDAGHFTS-RGLYSNPSGEPLSHNLLQLDGH--------KWRSLHA 134
            ..:|.::..|..|:.||...|..||.: |.:::..|.:. .|::..|.|.        :|:.:.:
  Fly    76 QRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDD-PHDMSNLFGSSLFSMRDARWKDMRS 139

  Fly   135 KSAEVFTPANMQKLLVRLSQIS-----------SRIQRDLGEKSLQTINISELVGAYNTDVMASM 188
            ..:..||.:.|:::...::|::           ||:|.:       .:::.:....:..||:||.
  Fly   140 TLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQEN-------ELDMKDYCTRFTNDVIAST 197

  Fly   189 AFGL-----VGQDNVEF---AKWTRNYWADFRMWQAYLALEFPLIARLLQYKSYAEPATAYFQKV 245
            ||||     ..::|..:   .|.|...:.....:..:.||:.  :.::|:.:.:...:|.||.::
  Fly   198 AFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKFMLFFALKG--LNKILKVELFDRKSTQYFVRL 260

  Fly   246 ALSQLQLHRRRD-------------RQPLQTFLQLYSNAEKPLTDIEIAGQAFGFVLAGLGPLNA 297
            .|..::..:..:             |..:|| .:..::|.:..:|.:|..|.|.|..||......
  Fly   261 VLDAMKYRQEHNIVRPDMINMLMEARGIIQT-EKTKASAVREWSDRDIVAQCFVFFFAGFETSAV 324

  Fly   298 TLAFCLYELARQPEVQDRTRLEINKALEE-HGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLR 361
            .:.|..:||....:||.|...|:.:..:: .|.::|.|.:..::|..||:||.||.......:.|
  Fly   325 LMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAIAVDR 389

  Fly   362 RATKE--FEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFG 424
            ...|:  |:|.|....:.||:.:.:||...|.||..:|||.:|.||||.::.:.|.....:.|||
  Fly   390 ECNKDITFDVDGQKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFTYFPFG 454

  Fly   425 DGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSD--IKLSVER 484
            .|.|.||.:|||..:....:..||:.:|:||:.::.||:|.......|.||..  ||| |:|
  Fly   455 LGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL-VQR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	121/480 (25%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	123/485 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461242
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900