DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6u1 and Cyp9h1

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_610820.1	Gene:	Cyp9h1 / 36412	FlyBaseID:	FBgn0033775	Length:	518	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	132/530 - (24%)
Similarity:	234/530 - (44%)	Gaps:	65/530 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MHRTLLTALGALSVVYALVKFSLG---YWKRRGILHEKPKFLWGNI--KGVVSGKRHAQDALQDI 63
            |.::::.....:.::..|.|:|:.   .:..||:.||||..|.|||  |.::.|....:..: ::
  Fly     1 MDQSMIALALFIILLVLLYKWSVAKYDVFSERGVSHEKPWPLIGNIPLKAMIGGMPVLKKMI-EL 64

  Fly    64 YTAYKGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTS-RGLYSNPSGEPLSHNLLQLDGH 127
            :|.:.| :|..|.||.........|.:|:..|...:..||.: ..:::|.....||.:|:.|...
  Fly    65 HTKHTG-SPVYGIYALRDAVFFVRDPELIKLIGIKEFDHFVNHNSMHNNIQESILSKSLISLRDG 128

  Fly   128 KWRSLHAKSAEVFTPANMQKLLVRLSQ-------ISSRIQRDLGEKSLQTINISELVGAYNTDVM 185
            :|:.:.......||.:.| :::..|.|       |..:.|.:|.:.:...:.:.:....:..||:
  Fly   129 RWKEMRNILTPAFTGSKM-RIMYDLIQSCSEEGVIHIQEQLELSQDASIELEMKDYFTRFANDVI 192

  Fly   186 ASMAFGL--------------VGQDNVEFAKWTRNYWADFRMWQAYLALEFPLIARLLQYKSYAE 236
            |::|||:              :||.....:.|:        :.:|.|...||.:.::|:.:....
  Fly   193 ATVAFGISINSFRRKDNEFFRIGQAMSRISAWS--------VVKAMLYALFPRLMKVLRIQVLDT 249

  Fly   237 PATAYFQKVALSQLQLHRRRDRQPLQTFLQLYSNA-EKPLTDI----------------EIAGQA 284
            ....||..:..:.:: :|:..:......:.|...| ::.|.|:                ::..|.
  Fly   250 KNIDYFSSLVTAAMR-YRQEHKVVRPDMIHLLMEAKQQRLADLSDKSKDELYYSEFTADDLLAQC 313

  Fly   285 FGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQ-VTPECLRELRYTKQVLNE 348
            ..|..||...::::|.|..:||...|.||||...||....||..|| :|.:.|.:::|...|:.|
  Fly   314 LLFFFAGFEIISSSLCFLTHELCLNPTVQDRLYEEIISVHEELKGQPLTYDKLTKMKYLDMVVLE 378

  Fly   349 TLRLHTPHPFLLRRATKE---FEVPG-SVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEE 409
            .||...|.....|...::   |:..| .:|...||:.:.||..::|.||..:|:|:.|.||||.:
  Fly   379 ALRKWPPSISTDRECRQDIDLFDENGQKLFSARKGDVLQIPIFSLHHDPENFEDPEFFNPERFAD 443

  Fly   410 -QARRSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLM 473
             .|..||   .::|||.|.|.||..|.|..:|...:..||...:..|:..||..:..|.|...|.
  Fly   444 GHALESR---VYMPFGVGPRNCIGNRMALMELKSIVYQLLLNFKLLPAKRTSRDLLNDIRGHGLK 505

  Fly   474 PKSDIKLSVE 483
            ||:...|..|
  Fly   506 PKNGFWLKFE 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	120/483 (25%)
Cyp9h1	NP_610820.1	p450	38..512	CDD:278495	122/488 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461230
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	9	8.900