DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	170/500 - (34%)
Similarity:	265/500 - (53%)	Gaps:	31/500 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRAPFVGFYAC 79
            |.:.|:|......||||:|:.||.|..:.||::|:|. |.|.:|..|.||..:||:.|..|.|..
  Fly    12 LGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVK-KYHFRDINQRIYKKFKGQGPIAGMYMF 75

  Fly    80 LKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSHNLLQLDGHKWRSLHAKSAEVFTPA- 143
            .|...|..||..:.|::..|..:|..||.::||..:||:.:|..|:|.:||::..|...|||..
  Fly    76 FKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFALEGEEWRAMRHKLTPVFTSGK 140

  Fly   144 --NMQKLLVRLS-QISSRIQRDLGEKSLQ--TINISELVGAYNTDVMASMAFGL----VGQDNVE 199
              .|.|::|.:. ::...:.:.:.|..::  .:.|.:|...:.|||:.|.||||    :...:.|
  Fly   141 IKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCARFTTDVIGSCAFGLECNSLQDPSAE 205

  Fly   200 FAKWTRNYWADFR---MWQAYLALEFPLIARLLQYKSYAEPATAYFQKVALSQLQLH-----RRR 256
            |.:..|..:...|   :.|:::.....| ||.|:.|...:..|.:|.....:.:...     :|.
  Fly   206 FRQKGREIFTRRRHSTLVQSFIFTNARL-ARKLRIKVLPDDLTQFFMSTVKNTVDYRLKNGIKRN 269

  Fly   257 D--RQPLQTFLQLYSNAEK--------PLTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPE 311
            |  .|.::...:....|:|        .||..::|.|||.|.:||....::|::.||||||.||:
  Fly   270 DFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQMAAQAFVFFVAGFETSSSTMSLCLYELALQPD 334

  Fly   312 VQDRTRLEINKALEE-HGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFEVPGSVFV 375
            :|.|.|.||...|.. .||::..:.|.::.|..|||:||||.|...|.|:|..||::::|.|..|
  Fly   335 IQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIV 399

  Fly   376 IAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQL 440
            :.||...|||...||.||.||..|::|.|.||:.:..::|...|:||||||.|.||..||.:.|.
  Fly   400 LDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQA 464

  Fly   441 LVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERV 485
            .:|||:|||:.:::.|..|.:|:.:..:..||.....|.|.||||
  Fly   465 KIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTTNDGIYLKVERV 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	154/465 (33%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	158/475 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	7	7.070