DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp28d1

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_608912.1	Gene:	Cyp28d1 / 33749	FlyBaseID:	FBgn0031689	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	142/511 - (27%)
Similarity:	226/511 - (44%)	Gaps:	48/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLTALGA-LSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGR 70
            |.|..:.| |:::|..:.::..|||:|||...|.....|:...|.:.||:....:.:||..||..
  Fly     6 TALFVIAAILALIYVFLTWNFSYWKKRGIPTAKSWPFVGSFPSVFTQKRNVVYDIDEIYEQYKNT 70

  Fly    71 APFVGFYACLKPFILALDLKLVHQIIFTD--AGHFTSRGLYSNPSGEP-LSHNLLQLDGHKWRSL 132
            ...||.:....|.::....:..|:|..:|  :.|......:::...:| |::|...|.|..|:.
  Fly    71 DSIVGVFQTRIPQLMVTTPEYAHKIYVSDFRSFHDNEMAKFTDSKTDPILANNPFVLTGEAWKE- 134

  Fly   133 HAKSAEVFTP---ANMQKLLVRLS-QISSRIQRDLGEKSL----QTINISELVGAYNTDVMASMA 189
              :.||| ||   ||..|....:| ::..:....:..:||    |.:|..:|...|.|:|::...
  Fly   135 --RRAEV-TPGLSANRVKAAYPVSLRVCKKFVEYIRRQSLMAPAQGLNAKDLCLCYTTEVISDCV 196

  Fly   190 FGLVGQ---DN----VEFAKWTRNYWADFR-MWQAYLALEFPLIARLLQYKSYAEPATAYFQKVA 246
            .|:..|   ||    |...|  |.:...|. ::...:|..:|.|.:......:|:...|:|..:.
  Fly   197 LGISAQSFTDNPTPMVGMTK--RVFEQSFGFIFYTVVANLWPPITKFYSVSLFAKDVAAFFYDLM 259

  Fly   247 LSQLQLHR------RRDRQPLQTFLQLYSNAEKPLTDIEIAGQAFGFVLAGLGPLNATLAFCLYE 305
            ...:|:.|      :|| ..|...|||  ..:|.|...|:......|:..|.......|...|..
  Fly   260 QKCIQVRRESPAAQQRD-DFLNYMLQL--QEKKGLNAAELTSHTMTFLTDGFETTAQVLTHTLLF 321

  Fly   306 LARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFEVP 370
            |||.|:.|.:.|.||..|      ::|.|.:.||.:|:..::||||:.:|.....:..|:..|:.
  Fly   322 LARNPKEQMKLREEIGTA------ELTFEQISELPFTEACIHETLRIFSPVLAARKVVTEPCELT 380

  Fly   371 GSVFVIAK---GNNVLIPTAAIHMDPGIYENPQRFYPERF---EEQARRSRPAAAFLPFGDGLRG 429
            ....|..|   |:.|:||..|:|.||..||.||.|.||||   ...|::.|....|..||||.|.
  Fly   381 NKNGVSVKLRPGDVVIIPVNALHHDPQYYEEPQSFKPERFLNINGGAKKYRDQGLFFGFGDGPRI 445

  Fly   430 CIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLS-VER 484
            |...||:..|:...||.::|......:.:|....|.|:...:...|..:.|. |||
  Fly   446 CPGMRFSLTQIKAALVEIVRNFDIKVNPKTRKDNEIDDTYFMPALKGGVWLDFVER 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	126/467 (27%)
Cyp28d1	NP_608912.1	p450	35..477	CDD:278495	124/456 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460954
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900