DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp309a2

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_608689.2	Gene:	Cyp309a2 / 33439	FlyBaseID:	FBgn0041337	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	128/523 - (24%)
Similarity:	217/523 - (41%)	Gaps:	70/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LMHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAY 67
            |:|..:|.       :|..:.:...||::||::..:|..|.|...|:::.|.:....:|.||..|
  Fly    42 LLHLLVLP-------IYLYLTWHHKYWRKRGLVTARPLTLLGTYPGLLTRKSNLVFDVQKIYDKY 99

  Fly    68 KGRAPFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPLSH---------NLLQ 123
            ||:...||.:...:|.||.||.:|.|:::.::     .|....:.....|.|         |...
  Fly   100 KGKHRAVGVFVTRQPQILVLDPELAHEVLVSN-----FRCYKDSLQSSYLRHAKWDKYARLNPFW 159

  Fly   124 LDGHKWRSLHAKSAEVFTPANMQKLLVRLSQ----ISSRIQRDLGEKSLQTINISELVGAYNTDV 184
            ..|..||.|...:....:.:.:::......|    ::..:.:.:.||: ..:...:|...|...|
  Fly   160 ASGQSWRRLRTDAQAGISGSRLRQAYNIWEQGGQMLTEYMTQQVAEKN-NILETRDLCFRYTAHV 223

  Fly   185 MASMAFGL--------VGQDN--VEFA-KWTRNYWADFRMWQAYLA-LEFPLIARLLQYKSYAEP 237
            ||...:|:        :.|.|  .|.| ||| :|  .|.|...::| :..|....||:::.|.:.
  Fly   224 MADFIWGIDAGTLTRPMEQPNKVQEMASKWT-SY--AFYMLTLFMATIVAPCSRLLLRFRFYPKE 285

  Fly   238 ATAYFQKVALSQLQLHRRRDRQPLQTFLQ--LYSNAEKPLTDIEIAGQAFGFVLAGLGPLNATLA 300
            ...:|..:....::|..:........:|.  |....:|..|..::.|.|...:|.|.......|.
  Fly   286 TDEFFSNLTKESIELRLKAGDSTRTDYLSHLLQLRDQKQATHDDLVGHALTVMLDGYDTSGTALL 350

  Fly   301 FCLYELARQPEVQDRTRLEI------NKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFL 359
            ..||.||..|.||.:.|:||      .|:|:.       |.|..|:|.:||:.|:|||.:    |
  Fly   351 HALYYLAENPAVQQKLRVEILSCMASEKSLDF-------EKLSSLQYLEQVIYESLRLSS----L 404

  Fly   360 LRRATKEFEVPGSVFV-------IAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQA-RRSRP 416
            :.:.||...:|..:.:       :..|..::||....|.|...:..|:.|.||||:..| :....
  Fly   405 IPQYTKVCTLPTVIRLSESKSLDVEVGMTIMIPNYQFHHDKQYFPEPEAFKPERFDNGAYQELMR 469

  Fly   417 AAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLS 481
            ...||||.||.|.|:....|...|...||.:|...:.....:..||.......::|  :.|:.|.
  Fly   470 KGIFLPFSDGPRICMGVPLAMLTLKSALVHILSNFQVVRGRDRLIPKGDSGFGVVL--QGDVNLE 532

  Fly   482 VER 484
            ..|
  Fly   533 YRR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	117/477 (25%)
Cyp309a2	NP_608689.2	p450	70..526	CDD:299894	117/477 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461002
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900