DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp6t1

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_608457.1	Gene:	Cyp6t1 / 33127	FlyBaseID:	FBgn0031182	Length:	529	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	136/504 - (26%)
Similarity:	223/504 - (44%)	Gaps:	60/504 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GALSVV-----YALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYK--GR 70
            |.|.||     :.::.|  .:|:|.|:.........||:..::.|.....|..:::|.:.:  ||
  Fly    27 GCLLVVTIVWLWQILHF--WHWRRLGVPFVPAAPFVGNVWNLLRGACCFGDQFRELYESKEAAGR 89

  Fly    71 APFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSRGLYSNPSGEPL-SHNLLQLDGHKWRSLHA 134
            | |||........:|..|..|:.:|:..|...|:||...::|:.:.: |.||.......||..|
  Fly    90 A-FVGIDVLHNHALLLRDPALIKRIMVEDFAQFSSRFETTDPTCDTMGSQNLFFSKYETWRETH- 152

  Fly   135 KSAEVFTP-------ANMQKLLVRLSQ-ISSRIQRDLGEKSLQTINISELVGAYNTDVMASMAFG 191
               ::|.|       .||..||..:.| :...:::.|..:....:.:.:|...:.||::||:|||
  Fly   153 ---KIFAPFFAAGKVRNMYGLLENIGQKLEEHMEQKLSGRDSMELEVKQLCALFTTDIIASLAFG 214

  Fly   192 LVGQDNVEFAKWTRNYWADF-------------RMWQAYLALEFPLIARLLQYKSYAEPATAYFQ 243
            :.       |...:|..|:|             |:...:....||.::..:....|:|....:.:
  Fly   215 IE-------AHSLQNPEAEFRRMCIEVNDPRPKRLLHLFTMFFFPRLSHRVGTHLYSEEYERFMR 272

  Fly   244 K---VALSQLQLHRRRDRQPLQTFLQLYSNAEKPLTDI-----EIAGQAFGFVLAGLGPLNATLA 300
            |   ..|||...........:..||||  ...:|...|     ..|.||...:|||....::|:.
  Fly   273 KSMDYVLSQRAESGENRHDLIDIFLQL--KRTEPAESIIHRPDFFAAQAAFLLLAGFDTSSSTIT 335

  Fly   301 FCLYELARQPEVQDRTRLEINKALE-EHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLR--R 362
            |.|||||:...:|||.|.|:..||: ....|::.:.:..|.|.:||::|.|||:.|..||.|  .
  Fly   336 FALYELAKNTTIQDRLRTELRAALQSSQDRQLSCDTVTGLVYLRQVVDEVLRLYPPTAFLDRCCN 400

  Fly   363 ATKEFEVP----GSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPF 423
            :...:::.    ||.|.:..|..|.|....||.|...:.||:.|.||||..:.|:......:|||
  Fly   401 SRTGYDLSPWNGGSPFKLRAGTPVYISVLGIHRDAQYWPNPEVFDPERFSAEQRQQHHPMTYLPF 465

  Fly   424 GDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLL 472
            |.|.||||.....:.::.|||:.:|...|......|...:.:|.:..:|
  Fly   466 GAGPRGCIGTLLGQLEIKVGLLHILNHFRVEVCERTLPEMRFDPKAFVL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	128/474 (27%)
Cyp6t1	NP_608457.1	p450	91..515	CDD:299894	120/437 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461074
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900