DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp308a1

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_573320.1	Gene:	Cyp308a1 / 32859	FlyBaseID:	FBgn0030949	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	142/493 - (28%)
Similarity:	218/493 - (44%)	Gaps:	56/493 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KFSLGYWKRRGILHEKPKFLW---GNIKGVVSGKRHAQDALQDIYTAYKGRAPFVGFYACL-KPF 83
            |:...:|:|.|:  |.| |.|   ||:.....|:|...:..|:|||...| ..:||||... :|.
  Fly    18 KWQGNHWRRLGL--EAP-FGWPLVGNMLDFALGRRSYGEIYQEIYTRNPG-LKYVGFYRLFNEPA 78

  Fly    84 ILALDLKLVHQII----FTDAGHFTSRGLYSNPSGEPL-SHNLLQLDGHKWRSLHAKSAEVFTPA 143
            ||..|.:|:.||:    |.|.   ....:|.:...:.| |||....:|.:||.|.|....:|||:
  Fly    79 ILVRDQELLRQILVGRNFADC---ADNAVYVDHQRDVLASHNPFIANGDRWRVLRADLVPLFTPS 140

  Fly   144 NMQKLLVRLSQISSRIQRDLGEKSLQTINISELVGAYNTDVMASMAFGL----------VGQDNV 198
            .:::.|..::: :.::.||  :..|......:|...|...|:||..|||          |..:..
  Fly   141 RVRQTLPHVAR-ACQLLRD--QVPLGRFEAKDLATRYTLQVVASAIFGLDAHCLGIHMRVAHEPS 202

  Fly   199 EFAKWTR-----NYWADFRMWQAYLALEFPLIARLLQYKSYAEPATAYFQKVALSQLQLHRRRDR 258
            .:.:|..     :.|:   :.:....|..|.:.||:.::....|...:|:::.         ..|
  Fly   203 RWLEWLAPLFQPSVWS---LLETMSLLHTPRLGRLIGHRYVPLPLQHWFRELV---------EAR 255

  Fly   259 QPLQTFLQLYSNAEKPLTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKA 323
            ......||..:.:::.|...|:||.|...:|.|.......|||.|||||...:.|.|..:|:::.
  Fly   256 SGGDNLLQWLAESKRGLGKEELAGHATTLLLEGYETSAMLLAFALYELALNEDAQRRLHIELDEV 320

  Fly   324 LEEHGGQ-VTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFEVP------GSVFVIAKGNN 381
            .:.|.|. :.|..|.||||::..|.|.||||.....|.:|.||.|.:|      .|...:..|..
  Fly   321 AQRHAGNLIDPVALGELRYSEAALLEALRLHPAMQALQKRCTKTFTLPDQKSGASSELKVHLGTV 385

  Fly   382 VLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVA 446
            :::|..|||:||.:|..|.:|.||||..|...   ...||.||.|.|.|...|....|....|..
  Fly   386 LVLPVQAIHLDPALYPAPNQFRPERFLNQPPM---GCRFLGFGAGPRMCPGMRLGLLQTKAALTT 447

  Fly   447 LLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVER 484
            ||:.|....:.|....||......|...::.|.||.:|
  Fly   448 LLQDHCVQLADEDQCRVEVSPLTFLTASRNGIWLSFKR 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	133/467 (28%)
Cyp308a1	NP_573320.1	p450	32..481	CDD:299894	134/471 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460942
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900