DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and erg5

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_593788.2	Gene:	erg5 / 2542469	PomBaseID:	SPAC19A8.04	Length:	543	Species:	Schizosaccharomyces pombe

Alignment Length:	540	Identity:	104/540 - (19%)
Similarity:	198/540 - (36%)	Gaps:	158/540 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRA 71
            |:..||.|:.:.|..:.:.:.                   ||.:.|.|.              :.
pombe    30 TICFALLAVCIAYDQISYQMQ-------------------KGHIPGPRF--------------KI 61

  Fly    72 PFVG-FYACLKPFILALDLK----------LVHQIIFTDAGHFTSRGLYSNPS---------GEP 116
            ||:| |...:||.....:.|          :.|:.:...:....:|.:.::||         |:.
pombe    62 PFMGSFLDSMKPTFEKYNAKWQTGPLSCVSVFHKFVVIASERDLARKILNSPSYVQPCVVDAGKK 126

  Fly   117 -LSH-NLLQLDGHKWRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEKS----------LQ 169
             |.| |.:.|||............:||...:...|.....:.::..::....|          .:
pombe   127 ILKHTNWVFLDGRDHIEYRKGLNGLFTTRALASYLPAQEAVYNKYFKEFLAHSKDDYAQYMIPFR 191

  Fly   170 TINIS----ELVGAYNTDVMASMAFGLVGQDNVEFAKWTRNYWADFRMWQAYLALE---FPLIAR 227
            .||::    ...|.|.:|            |.::       :.|| ..|:...|:|   ||::..
pombe   192 DINVATSCRTFCGYYISD------------DAIK-------HIAD-EYWKITAAMELVNFPIVLP 236

  Fly   228 L------LQYKSYAEPATAYFQKVA---------------LSQLQLHRRRDRQPLQTFLQLYSNA 271
            .      :|.:   :....||.|.|               :.:..:|...:.:..::  :....|
pombe   237 FTKVWYGIQSR---KVVMRYFMKAAAESRKNMEAGNAPACMMEEWIHEMIETRKYKS--ENKEGA 296

  Fly   272 EKP------LTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTR---LEINKALEEH 327
            |||      .:|.||:.....|:.|.....::.:.:....||..|:|..:.|   |.|.|
pombe   297 EKPSVLIREFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVREEQLRIRK----- 356

  Fly   328 GGQV----TPECLRELRYTKQVLNETLRLHTP---HPFLLRRA---TKEFEVPGSVFVIAKGNNV 382
             |.:    :.:.:.::.||:.|:.|.|||..|   .|:.:::|   |.::.||....|
pombe   357 -GDIDVPLSLDLMEKMTYTRAVVKECLRLRPPVLMVPYRVKKAFPITPDYTVPKDAMV------- 413

  Fly   383 LIPT--AAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQLL--VG 443
             |||  .|:| |..:|..|:.|.|:|:.......:....::.||:|...|:..|:|...|:  :|
pombe   414 -IPTLYGALH-DSKVYPEPETFNPDRWAPNGLAEQSPKNWMVFGNGPHVCLGQRYAVNHLIACIG 476

  Fly   444 LVALLR--QHRYAPSAETSI 461
            ..:::.  :|:..|.::|.:
pombe   477 KASIMLDWKHKRTPDSDTQM 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	99/509 (19%)
erg5	NP_593788.2	CypX	57..505	CDD:225035	96/494 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
TreeFam	0	0.000	Not matched by this tool.
	3	3.050