DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_036819.1	Gene:	Tbxas1 / 24886	RGDID:	3826	Length:	533	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	151/543 - (27%)
Similarity:	242/543 - (44%)	Gaps:	98/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTAYKGRA 71
            ||...|.||...|:...||  ..::.||.|.:|....||:.....|...:...|::.|      .
  Rat    19 TLSVVLLALLKWYSTSAFS--RLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERY------G 75

  Fly    72 PFVGFYACLKPFILALDLKLVHQIIFTDAGHFTSR---GLYSNPSGEP--LSHNLLQLDGHKWRS 131
            |..|:|...:.:|:..|..::.:::..:..:|::|   ||      ||  ::.::|.|...:|..
  Rat    76 PLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGL------EPKLIADSVLMLRDRRWEE 134

  Fly   132 LHAKSAEVFTPANMQKLLVRLSQISSRIQRDL--GEKSLQTINISELVGAYNTDVMASMAFGLV- 193
            :.......|:|..:.::...:||....:...|  ...|....:|......:.|:|:||:|||:.
  Rat   135 VRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEV 199

  Fly   194 -GQDNVE--FAKWTRNYWADFRMWQAYLA--LEFPLI----ARLLQYKSYAEPATAYFQKVALSQ 249
             .||..|  |.:..:..:| |...:..||  |.||.|    ||:|..|:..| ...:|..:..:.
  Rat   200 NSQDAPEDPFVQHCQRVFA-FSTPRPLLALILSFPSIMVPLARILPNKNRDE-LNGFFNTLIRNV 262

  Fly   250 LQLHRRRDRQPLQ----TFLQLYSNAE-------------------------------------K 273
            :.|   ||:|..:    .|||:..:|:                                     |
  Rat   263 IAL---RDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAK 324

  Fly   274 PLTDIEIAGQAFGFVLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPE-C-L 336
            |||..|||||||.|::||......||:|..|.||..||.|:|...|::..:|:|   ..|| | |
  Rat   325 PLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKH---PAPEYCNL 386

  Fly   337 RE-LRYTKQVLNETLRLHTPHPFLLRRATKEFEV------PGSVFVIAKGNNVLIPTAAIHMDPG 394
            :| |.|...|:.||||::.|.....|.|.::.||      .|||..||.|        |:|.||.
  Rat   387 QEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVG--------ALHHDPE 443

  Fly   395 IYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAET 459
            .:.||:.|.||||..:||..:....:||||.|.|.|:..|.....:.:.|:.:|.:.|:....||
  Rat   444 HWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPET 508

  Fly   460 SIPVEYDNRRLLLMPKSDIKLSV 482
            .:|::.:::. .|.||:.:.:.:
  Rat   509 QVPLQLESKS-ALCPKNGVYVKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	138/503 (27%)
Tbxas1	NP_036819.1	p450	47..530	CDD:278495	140/511 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820