DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6u1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001286149.1	Gene:	Cyp6u1 / 35608	FlyBaseID:	FBgn0033121	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	146/522 - (27%)
Similarity:	244/522 - (46%)	Gaps:	64/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLMHRTLLTALGALSVVYALVKF----SLGYWKRRGILHEKPKFLWGNIKGVVSG----KRHAQ 57
            |||:....|.....|:.:..|:..    :.|.:|:.||...||....|||.....|    .||..
  Rat     1 MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPLPFVGNILAYRHGFWEFDRHCH 65

  Fly    58 DALQDIYTAYKGRAPFVGFYACLKPFILAL-DLKLVHQIIFTDA-GHFTSRGLYSNPSGEPLSHN 120
            ....||:..|:||.|           |||: |..::..::..:. ..||:|..: .|:| .|...
  Rat    66 KKYGDIWGFYEGRQP-----------ILAITDPDIIKTVLVKECYSTFTNRRSF-GPAG-ILKKA 117

  Fly   121 LLQLDGHKWRSLHAKSAEVFTPANMQKLLVRLSQISSRIQRDL---GEKSLQTINISELVGAYNT 182
            :...:..:|:.|....:..||...::::...::|.:..:.:::   .||. ..|.:.::.|||:.
  Rat   118 ITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNVKHEAEKG-NPITMKDIFGAYSM 181

  Fly   183 DVMASMAFGLVGQDNVEFAKWTRNYWAD-------FRMWQAYL--ALEFPLIARLLQYKSYAEPA 238
            ||:...:||:    ||:.....:|.:..       |.....:.  .:.||.:..:.:    |...
  Rat   182 DVITGTSFGV----NVDSLNNPQNPFVQKVKKLLKFNFLDPFFLSVILFPFLTPVFE----AFDI 238

  Fly   239 TAY------FQKVALSQLQLHRRRD--RQPLQTFLQLYSNAE--------KPLTDIEIAGQAFGF 287
            |.:      |.:.::.:::.:|.::  :|.|. ||||..|::        :.|||:||..|:..|
  Rat   239 TVFPKDVMKFFRTSVERMKENRMQEKVKQRLD-FLQLMINSQSSGDKESHQGLTDVEIVAQSIFF 302

  Fly   288 VLAGLGPLNATLAFCLYELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRL 352
            :.||....::.|:|.||.||..|::|.:.:.||:.|| .:...||.:.|.|:.|...||||||||
  Rat   303 IFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL-PNKAPVTYDVLVEMEYLDMVLNETLRL 366

  Fly   353 HTPHPFLLRRATKEFEVPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPA 417
            ......|.|...|:.|:.| || |.||..|::||.|:|.||..:..|:.|.||||.::.:.|...
  Rat   367 FPVGGRLERVCKKDVEING-VF-IPKGTVVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINP 429

  Fly   418 AAFLPFGDGLRGCIAARFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSV 482
            ..:||||:|.|.||..|||...:.:.||.:|:...:....||.||::...:......|..|..:|
  Rat   430 YIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAV 494

  Fly   483 ER 484
            .|
  Rat   495 SR 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	132/470 (28%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	133/477 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820