Protein Alignment Cyp6u1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_001286149.1
• Gene: Cyp6u1 / 35608
• FlyBaseID: FBgn0033121
• Length: 488
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 139/508 - (27%)
• Similarity: 245/508 - (48%)
• Gaps: 39/508 - (7%)

  Fly     2 DLMHRTLLTALGALSVVYALVKFSLGYWKRRGILHEKPKFLWGNIKGVVSGKRHAQDALQDIYTA 66
            ||...|.|....:|.::|.....|.|.:|:.||....|....|||...     |....:.|: ..
Human     6 DLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSY-----HKGFCMFDM-EC 64

  Fly    67 YKGRAPFVGFYACLKPFILALDLKLVHQIIFTDA-GHFTSRGLYSNPSGEPLSHNLLQLDGHKWR 130
            :|......|||...:|.:...|..::..::..:. ..||:|..: .|.|...|...:..| .:|:
Human    65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPF-GPVGFMKSAISIAED-EEWK 127

  Fly   131 SLHAKSAEVFTPANMQKLLVRLSQISSRIQRDLGEKSLQT---INISELVGAYNTDVMASMAFGL 192
            .|.:..:..||...:::::..::|....:.|:| .:..:|   :.:.::.|||:.||:.|.:||
Human   128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL-RREAETGKPVTLKDVFGAYSMDVITSTSFG- 190

  Fly   193 VGQDNVE-----FAKWTRNYWA-DFRMWQAYLALE-FPLIARLLQYKS---YAEPATAYFQKVAL 247
            |..|::.     |.:.|:.... || :...:|::. ||.:..:|:..:   :....|.:.:| ::
Human   191 VNIDSLNNPQDPFVENTKKLLRFDF-LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK-SV 253

  Fly   248 SQLQLHRRRDRQPLQT-FLQLY--------SNAEKPLTDIEIAGQAFGFVLAGLGPLNATLAFCL 303
            .:::..|..|.|..:. ||||.        :.:.|.|:|:|:..|:..|:.||....::.|:|.:
Human   254 KRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318

  Fly   304 YELARQPEVQDRTRLEINKALEEHGGQVTPECLRELRYTKQVLNETLRLHTPHPFLLRRATKEFE 368
            ||||..|:||.:.:.||:..| .:....|.:.:.::.|...|:||||||......|.|...|:.|
Human   319 YELATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382

  Fly   369 VPGSVFVIAKGNNVLIPTAAIHMDPGIYENPQRFYPERFEEQARRSRPAAAFLPFGDGLRGCIAA 433
            :.|  ..|.||..|:||:.|:|.||..:..|::|.||||.::.:.:.....:.|||.|.|.||..
Human   383 ING--MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445

  Fly   434 RFAEQQLLVGLVALLRQHRYAPSAETSIPVEYDNRRLLLMPKSDIKLSVERVD 486
            |||...:.:.|:.:|:...:.|..||.||::. :...||.|:..:.|.||..|
Human   446 RFALMNMKLALIRVLQNFSFKPCKETQIPLKL-SLGGLLQPEKPVVLKVESRD 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6u1	NP_001286149.1	p450	38..475	CDD:299894	123/459 (27%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	125/469 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920