DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPINH1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	425	Identity:	99/425 - (23%)
Similarity:	169/425 - (39%)	Gaps:	52/425 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SLLLLQGLNLAMANTLNYSKSPAG--------------------EAQFASQLFGQLAKSQSGRNI 52
            |||||....|..|......|.||.                    .|..|..|:..:||.|:..||
Human     3 SLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENI 67

  Fly    53 VFSPSSIRTGLALAYLGAEGSTADELKLGLGLE-------GAGKTEVAEKLDQLLAKG-QWEKAS 109
            :.||..:.:.|.|..||.:.:||.:.|..|..|       .||..|:...|....|:. .|
Human    68 LVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTW---- 128

  Fly   110 GDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQI 174
                    |..:|::..........:.....:::......:||..|....:.||.|..:.|..::
Human   129 --------KLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKL 185

  Fly   175 KDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGEL 239
            .::  .:.::....|:||||::||..|...|.........|:......|.|..|.:...:.:.:.
Human   186 PEV--TKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDD 248

  Fly   240 TELKAKVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEF 304
            .:.|.::||:|........:|::|...:.|..:|:.|....|.....:::::.|.:.|||...|.
Human   249 EKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEV 313

  Fly   305 DVPLQAALEELGIKKLFSPG-ANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVE 368
            ...||..|..||:.:..... |:||.: .|.:.|.::.|.|....|::..|.......:.:..:.
Human   314 THDLQKHLAGLGLTEAIDKNKADLSRM-SGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELR 377

  Fly   369 SLTIGEEVFEFIADHPFFFAIKDAQ--NTLFLGHV 401
            |..:      |.|||||.|.::|.|  :.||:|.:
Human   378 SPKL------FYADHPFIFLVRDTQSGSLLFIGRL 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	89/400 (22%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	89/392 (23%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920