DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn42De and zgc:173729

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001103200.1	Gene:	zgc:173729 / 798311	ZFINID:	ZDB-GENE-071004-64	Length:	439	Species:	Danio rerio

Alignment Length:	448	Identity:	136/448 - (30%)
Similarity:	220/448 - (49%)	Gaps:	74/448 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 NLAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKL 80
            :|:.|||           ||:..||.:::...:..|:.:||.||.:.||:..|||:|:|||::..
Zfish     3 SLSAANT-----------QFSLNLFKKISGGNASGNVFYSPVSISSALAMVSLGAKGNTADQMFK 56

  Fly    81 GLG-----------------------------------LEGAGKTEVAEKLDQLLAK---GQ--- 104
            .||                                   |:...|.|:...|.:..|:   ||
Zfish    57 VLGFNNPPKPGGATPTPAQATQKPQITCGVKSQHEPQALQQPQKFELPADLKKCPAQPVPGQKAE 121

  Fly   105 ------WEKASGDEDVPKLKY----ANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTA 159
                  :.|...:.:.|...|    |||::..|.::..:.:.......:||..|.|:|..|::.:
Zfish   122 EQIHSSFNKFMSELNKPGAPYVLSLANRLYGEQTYQFLEKFLSDAKTYYAAGLEKVDFKNKSEAS 186

  Fly   160 K-HINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKV 223
            : :||.|||:.|.::||||:...::||.|..:||||||||.:|:..|...||....|..:..:..
Zfish   187 RVNINKWVEKNTQEKIKDLLPSGAIDAMTRLVLVNAIYFKGNWEKKFTKEATRDGQFKLNKNQTK 251

  Fly   224 SVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQ----GLAIVEEKLMGIDLNEI 284
            .|..|.|:..|....:.|:.::|:||||.|.::..|||||.:.:    ||..:|:.|....|.|.
Zfish   252 PVKMMHQKARFSLASIPEMNSQVLELPYAGKNLSMLIILPDQIEDATTGLQKLEKALTYEKLMEW 316

  Fly   285 S--SQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLFSP-GANLSSLYQGSEPLRISEVKHKA 346
            :  |.:.:::|:|.|||||.|....:::.|..:|::.:|.| ..||:.: ..|..|.:|:|.|||
Zfish   317 TKPSMMCQQEVQVSLPKFKTEQTYDMKSLLVSMGMEDVFDPQKVNLTGM-SSSNDLVLSKVIHKA 380

  Fly   347 IIEVNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIK--DAQNTLFLGHVS 402
            .:||||:||.|:.||.:..::.|:.:.... .|.|||||.|.|:  .....||.|..|
Zfish   381 FVEVNEEGTEAAAATGVIATLTSMPLSPPK-TFTADHPFIFFIRHNPTNAILFYGRFS 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	131/430 (30%)
zgc:173729	NP_001103200.1	SERPIN	4..439	CDD:294093	136/447 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2586
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8430
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.760