DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Spn42De and Serpind1

DIOPT Version :9

Sequence 1:NP_610246.3 Gene:Spn42De / 35602 FlyBaseID:FBgn0033115 Length:404 Species:Drosophila melanogaster
Sequence 2:NP_077358.1 Gene:Serpind1 / 79224 RGDID:619854 Length:479 Species:Rattus norvegicus


Alignment Length:412 Identity:113/412 - (27%)
Similarity:191/412 - (46%) Gaps:49/412 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLLLQGLN-LAMANTLNYSKSPAGEAQFASQLFGQLAKSQ--SGRNIVFSPSSIRTGLALAYLGA 70
            |.|.||.: :...|.||        |:||..|: ::.|.|  |..||..:|..|.|.:.:..||.
  Rat    94 LQLFQGKSRIQRLNILN--------AKFAFNLY-RVLKDQATSSDNIFIAPVGISTAMGMISLGL 149

  Fly    71 EGSTADELKLGLG----LEGAGKTEVA------EKLDQLLAKGQWEKASGDEDVPKLKYANRIFV 125
            .|.|.:|:...|.    :..:.|.||.      .||...|.:..:...        |:..|.:::
  Rat   150 RGETHEEVHSVLHFKDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYT--------LQSVNDLYI 206

  Fly   126 TQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESLDADTSAI 190
            .::|.:.:.::..:.:.:.|.|:..:|:..|..:| .||.:.:.|...||:  |.|:.|:.|..:
  Rat   207 QKQFPIREDFKAAMREFYFAEAQEADFSDPAFISK-ANSHILKLTKGLIKE--ALENTDSATQMM 268

  Fly   191 LVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTD 255
            ::|.||||..|.:.||...|:..:|..:....|.|..|..:..|......||...:::|.|.| .
  Rat   269 ILNCIYFKGAWMNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-G 332

  Fly   256 IVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKL 320
            |..||::|::..|:..:|.:|....:......:..|...|.|||||.|.:..|...|:.:||.||
  Rat   333 ISMLIVIPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKL 397

  Fly   321 FSPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGAT---FIKVSVESLTIGEEVFEFIAD 382
            |:...|:|.:  ..:.:.|...||::.|.|||:||.|:..|   |:.:|.:        ..|..|
  Rat   398 FNKNGNMSGI--SDQRIIIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQ--------VRFTVD 452

  Fly   383 HPFFFAIKDAQNT--LFLGHVS 402
            .||.|.:.:.:.:  ||:|.|:
  Rat   453 RPFLFLVYEHRTSCLLFMGRVA 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spn42DeNP_610246.3 SERPIN 31..401 CDD:238101 105/386 (27%)
Serpind1NP_077358.1 HCII 44..477 CDD:239002 113/412 (27%)
2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like) 55..79
Glycosaminoglycan-binding site. /evidence=ECO:0000250 172..192 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D556621at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11461
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.020

Return to query results.
Submit another query.