DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPINA7

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_006724746.1	Gene:	SERPINA7 / 6906	HGNCID:	11583	Length:	425	Species:	Homo sapiens

Alignment Length:	430	Identity:	111/430 - (25%)
Similarity:	188/430 - (43%)	Gaps:	55/430 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLQGLNLAMANTLNYSKSPAGE--------------------AQFASQLFGQLAKSQSGRNIV 53
            :||:.||:..:     :..||.|:                    |.||..|:.:.......:||.
Human     8 VLLVLGLHATI-----HCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVETPDKNIF 67

  Fly    54 FSPSSIRTGLALAYLGAEGSTADEL--KLGLGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPK 116
            |||.||...|.:...||..||..|:  .||..|......|:......|:....:.|..     .:
Human    68 FSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLNFPKKE-----LE 127

  Fly   117 LKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPE 181
            |:..|.:|:.:..|....:.:.|...:.....:.:|:..:...:.|||.||.||..::..||  :
Human   128 LQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQTKGKVVGLI--Q 190

  Fly   182 SLDADTSAILVNAIYFKADWQSSF-PDYATYASDFVNHGGRKVSVDTMSQ-EDYFRFGELTELKA 244
            .|..:|..:|||.|:|||.|.:.| |.....:|.|:......|.|..|.| |.|:...:: ||..
Human   191 DLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYYHLVDM-ELNC 254

  Fly   245 KVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQ 309
            .|:::.|: .:.:.|.:||:|.| :..||..:....|.:.:..|::..|.:.:|||.......|.
Human   255 TVLQMDYS-KNALALFVLPKEGQ-MESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLG 317

  Fly   310 AALEELGIKKLFSPGANLSSLYQGSEPLRIS----------EVKHKAIIEVNEKGTTASGATFIK 364
            |.|.::||:..:|..|:.|.|.: ...|::|          :..|||::.:.||||.|:....::
Human   318 ATLLKMGIQHAYSENADFSGLTE-DNGLKLSNRPAGFVLPTQAAHKAVLHIGEKGTEAAAVPEVE 381

  Fly   365 VSVE-SLTIGEEVFEFIADHPFFFAI--KDAQNTLFLGHV 401
            :|.: ..|....:.:.  |..|...|  :..::.||||.|
Human   382 LSDQPENTFLHPIIQI--DRSFMLLILERSTRSILFLGKV 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	104/406 (26%)
SERPINA7	XP_006724746.1	alpha-1-antitrypsin_like	46..419	CDD:239011	103/385 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010