DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpinb1a

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_079705.2	Gene:	Serpinb1a / 66222	MGIID:	1913472	Length:	379	Species:	Mus musculus

Alignment Length:	404	Identity:	141/404 - (34%)
Similarity:	209/404 - (51%)	Gaps:	50/404 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLG 81
            |:.||||           ||.:||..|.:|....||.|||.||.:.||:..|||:||||.:|
Mouse     4 LSSANTL-----------FALELFQTLNESSPTGNIFFSPFSISSALAMVILGAKGSTAAQL--- 54

  Fly    82 LGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPK------LKYANRIFVTQRFKLTQTYQDLVS 140
                  .||...:.::.:.::.|    |.:.:|.|      ||.|||::..:.:.....|.....
Mouse    55 ------SKTFHFDSVEDIHSRFQ----SLNAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASTQ 109

  Fly   141 KNFAAAAENVNFTQKA-DTAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSS 204
            |.:.|....|:|...: |..|.||.||:.||..:|.:|::...:|:.|..:||||||||..|:..
Mouse   110 KMYGADLAPVDFLHASEDARKEINQWVKGQTEGKIPELLSVGVVDSMTKLVLVNAIYFKGMWEEK 174

  Fly   205 FPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQ----E 265
            |....|..:.|........:|..|.|:..|.||.:::||.||:|:||.|.::..:|:||:    |
Mouse   175 FMTEDTTDAPFRLSKKDTKTVKMMYQKKKFPFGYISDLKCKVLEMPYQGGELSMVILLPKDIEDE 239

  Fly   266 EQGLAIVEEKLMGIDLNEISSQLRRRK-----VRVQLPKFKFEFDVPLQAALEELGIKKLFSPG- 324
            ..||..:|::   |.|.::....:|..     |.|:||:||.|....|.:.|..||::.|||..
Mouse   240 STGLKKIEKQ---ITLEKLLEWTKRENLEFIDVHVKLPRFKIEESYTLNSNLGRLGVQDLFSSSK 301

  Fly   325 ANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAI 389
            |:||.: .||..|.||::.||:.:||||:||.|:.||. .::...:.:.||  ||..||||.|.|
Mouse   302 ADLSGM-SGSRDLFISKIVHKSFVEVNEEGTEAAAATG-GIATFCMLLPEE--EFTVDHPFIFFI 362

  Fly   390 K--DAQNTLFLGHV 401
            :  ...|.||||.|
Mouse   363 RHNPTSNVLFLGRV 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	135/388 (35%)
Serpinb1a	NP_079705.2	serpinB1_LEI	1..379	CDD:381028	141/404 (35%)
Serpinb1a	NP_079705.2	CARD-binding motif (CBM). /evidence=ECO:0000250\|UniProtKB:P30740	351..379		14/26 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830