DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPINE3

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001094790.1	Gene:	SERPINE3 / 647174	HGNCID:	24774	Length:	424	Species:	Homo sapiens

Alignment Length:	390	Identity:	100/390 - (25%)
Similarity:	173/390 - (44%)	Gaps:	40/390 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKL 96
            :.:||..|:..:|..::..|.|.||:.:...|.:...||||||..:|...||.....| .|.:.|
Human    30 KTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDK-RVKDFL 93

  Fly    97 DQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKH 161
            ..:.|... ..:.|.|    ::.|..:||.....|:..:.:.||....::.|..:.::...||..
Human    94 HAVYATLP-TSSQGTE----MELACSLFVQVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTAIQ 153

  Fly   162 INSWVEEQT-------------HQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYAS 213
            .:.....:|             .:|:....|        ..:||:.:.|:..|:..|....|...
Human   154 TSEGASRETAGGGPSEGPGGWPWEQVSAAFA--------QLVLVSTMSFQGTWRKRFSSTDTQIL 210

  Fly   214 DFVNHGGRKVSVDTMSQEDYFRFGELTEL---KAKVVELPYTGTDIVFLIILPQE-EQGLAIVEE 274
            .|....|..:.|..|.|.....:|:..:.   :..|:||||.|:.:...::||:: :..|:.:|.
Human   211 PFTCAYGLVLQVPMMHQTTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFLVLPRDKDTPLSHIEP 275

  Fly   275 KLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLFSP-GANLSSLYQGSEPLR 338
            .|....::..::.|||.::.|.||:|:.:....|::.|...|:..||.| .|||..: .|.:...
Human   276 HLTASTIHLWTTSLRRARMDVFLPRFRIQNQFNLKSILNSWGVTDLFDPLKANLKGI-SGQDGFY 339

  Fly   339 ISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIKDAQN--TLFLGHV 401
            :||..|||.|||.|:||.|||||.:.:...|     .:..|.||.||.:.:::...  |:|...:
Human   340 VSEAIHKAKIEVLEEGTKASGATALLLLKRS-----RIPIFKADRPFIYFLREPNTGITVFFDRI 399

Fly 402 401
Human 400 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	100/388 (26%)
SERPINE3	NP_001094790.1	SERPIN	31..399	CDD:238101	100/387 (26%)
SERPINE3	NP_001094790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..174		3/30 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020