Protein Alignment Spn42De and SERPINE3

DIOPT Version :10

• Sequence 1: NP_610246.3
• Gene: Spn42De / 35602
• FlyBaseID: FBgn0033115
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_001094790.1
• Gene: SERPINE3 / 647174
• HGNCID: 24774
• Length: 424
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 100/390 - (25%)
• Similarity: 173/390 - (44%)
• Gaps: 40/390 - (10%)

  Fly    32 EAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKL 96
            :.:||..|:..:|..::..|.|.||:.:...|.:...||||||..:|...||.....| .|.:.|
Human    30 KTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDK-RVKDFL 93

  Fly    97 DQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKH 161
            ..:.|... ..:.|.|    ::.|..:||.....|:..:.:.||....::.|..:.::...||..
Human    94 HAVYATLP-TSSQGTE----MELACSLFVQVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTAIQ 153

  Fly   162 INSWVEEQT-------------HQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYAS 213
            .:.....:|             .:|:....|        ..:||:.:.|:..|:..|....|...
Human   154 TSEGASRETAGGGPSEGPGGWPWEQVSAAFA--------QLVLVSTMSFQGTWRKRFSSTDTQIL 210

  Fly   214 DFVNHGGRKVSVDTMSQEDYFRFGELTEL---KAKVVELPYTGTDIVFLIILPQE-EQGLAIVEE 274
            .|....|..:.|..|.|.....:|:..:.   :..|:||||.|:.:...::||:: :..|:.:|.
Human   211 PFTCAYGLVLQVPMMHQTTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFLVLPRDKDTPLSHIEP 275

  Fly   275 KLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLFSP-GANLSSLYQGSEPLR 338
            .|....::..::.|||.::.|.||:|:.:....|::.|...|:..||.| .|||..: .|.:...
Human   276 HLTASTIHLWTTSLRRARMDVFLPRFRIQNQFNLKSILNSWGVTDLFDPLKANLKGI-SGQDGFY 339

  Fly   339 ISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIKDAQN--TLFLGHV 401
            :||..|||.|||.|:||.|||||.:.:...|     .:..|.||.||.:.:::...  |:|...:
Human   340 VSEAIHKAKIEVLEEGTKASGATALLLLKRS-----RIPIFKADRPFIYFLREPNTGITVFFDRI 399

  Fly   402  401
            Human   400  399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	serpin42Dd-like_insects	30..403	CDD:381070	100/390 (26%)
SERPINE3	NP_001094790.1	serpinE3	18..400	CDD:381040	100/390 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	143..174		3/30 (10%)