DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and serpinb1l2

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001038636.1	Gene:	serpinb1l2 / 568898	ZFINID:	ZDB-GENE-041001-117	Length:	382	Species:	Danio rerio

Alignment Length:	398	Identity:	135/398 - (33%)
Similarity:	204/398 - (51%)	Gaps:	40/398 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLG 81
            ::.||:|           ||..|:..|:.|.:..||.|||.||...|::.||||.|.||.|::..
Zfish     4 VSRANSL-----------FALDLYRALSASSAEGNIFFSPLSISAALSMVYLGARGDTAGEMEKV 57

  Fly    82 LGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAA 146
            |.....  ::.......|::......||     ..|:.|||::..:.|.....|.|...|.:.|.
Zfish    58 LCFSSV--SDFHAHFKTLISSINSPSAS-----YILRLANRLYGEKTFSFLPMYVDSTMKLYHAE 115

  Fly   147 AENVNFTQKADTAKH-INSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYAT 210
            .:.|:|.:.||.::. ||.|||:||..|||||:.|..::..|..:||||||||.:|..:|..:||
Zfish   116 PQTVDFIRAADDSRQFINKWVEKQTENQIKDLLQPGVVNEMTRLLLVNAIYFKGNWMHTFDAHAT 180

  Fly   211 YASDFVNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQE----EQGLAI 271
            ....|..:......|..|.|.:.|.:..:.|.|.:|:|||||..::..||:||.|    ...|..
Zfish   181 KEMPFKINQNESRPVQMMDQVENFPYRCIPEYKLQVLELPYTQQELSMLILLPDEIKYGSDPLLK 245

  Fly   272 VEEKLMGIDLNEISSQLRR------RKVRVQLPKFKFEFDVPLQAALEELGIKKLF-SPGANLSS 329
            :|.:|   :|.::.....|      ||:.|:|||||.|.:..|...||::|:..:| ...|:|:.
Zfish   246 LESEL---NLQKLLDWTSRGKMDTWRKIIVRLPKFKLEIESCLSETLEKMGMSSVFQETKADLTG 307

  Fly   330 LYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVF-EFIADHPFFFAIK--D 391
            : ..:..|.:|.|.|||.:||||:||.|:.||.:.:.:.:.   :..| :|||||||.|.|:  .
Zfish   308 M-SSNGGLFLSAVIHKAFVEVNEEGTEAAAATALLLPISAC---QGAFHDFIADHPFMFFIRHNP 368

  Fly   392 AQNTLFLG 399
            ..:.||||
Zfish   369 TNSILFLG 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	132/384 (34%)
serpinb1l2	NP_001038636.1	SERPIN	5..381	CDD:294093	135/397 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8430
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.860