DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPINB10

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_005015.1	Gene:	SERPINB10 / 5273	HGNCID:	8942	Length:	397	Species:	Homo sapiens

Alignment Length:	412	Identity:	135/412 - (32%)
Similarity:	210/412 - (50%)	Gaps:	48/412 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLGL 82
            ::|.::|         |||.:|..:||:|..|:||.||..||.|.|.:.||||:|:||.::...|
Human     3 SLATSIN---------QFALELSKKLAESAQGKNIFFSSWSISTSLTIVYLGAKGTTAAQMAQVL 58

  Fly    83 ------GLEGAGKTEVAEKLDQLLAKGQWEKASGD-----------EDVPKLKYANRIFVTQRFK 130
                  |::...::|...|::..|:..  |:...|           .|...||.||.|:..:.:.
Human    59 QFNRDQGVKCDPESEKKRKMEFNLSNS--EEIHSDFQTLISEILKPNDDYLLKTANAIYGEKTYA 121

  Fly   131 LTQTYQDLVSKNFAAAAENVNFTQKAD-TAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNA 194
            ....|.:.:...|.|..:.|||.:.:| ..|.||||||.||..:|::|:..:|:|:.|..|||||
Human   122 FHNKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVERQTEGKIQNLLPDDSVDSTTRMILVNA 186

  Fly   195 IYFKADWQSSFPDYATYASDF-VNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVF 258
            :|||..|:..|....|....| :|....| .|..|..:.......:.:.||..::|.|...|:..
Human   187 LYFKGIWEHQFLVQNTTEKPFRINETTSK-PVQMMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSL 250

  Fly   259 LIILPQEEQGLAIVEEKLMGIDLNEISS--QLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLF 321
            ||:||::..||..:|:.:....|||.:|  .:...:|::.|||||.|....|::.|..:|:...|
Human   251 LILLPEDINGLEQLEKAITYEKLNEWTSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAF 315

  Fly   322 SPG-ANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTA---SGATF-IKVSVESLTIGEEVFEFIA 381
            |.. |:.|.: ..:..|.:|.|.|||.:|:||:||.|   ||:.. |::.|.|:       ||.|
Human   316 SQSKADFSGM-SSARNLFLSNVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSI-------EFNA 372

  Fly   382 DHPFFFAIK-DAQNT-LFLGHV 401
            :|||.|.|: :..|| ||.|.:
Human   373 NHPFLFFIRHNKTNTILFYGRL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	133/397 (34%)
SERPINB10	NP_005015.1	PAI-2	4..397	CDD:239013	135/411 (33%)
SERPINB10	NP_005015.1	Nuclear localization signal	74..77		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3483
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.860