DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and serpine2

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_956478.1	Gene:	serpine2 / 393153	ZFINID:	ZDB-GENE-040426-848	Length:	395	Species:	Danio rerio

Alignment Length:	418	Identity:	119/418 - (28%)
Similarity:	196/418 - (46%)	Gaps:	39/418 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVKATCSLL-LLQGLNLAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLA 64
            |.|...|.:| ||..::::.:.:.:|.   |..:....|:|.|:.:.::..|::.||..:.:.|.
Zfish     1 MCVLFRCGVLFLLCSVSVSQSQSSSYG---ARGSDLGLQVFMQVLQDRAQENVLLSPHGVASVLG 62

  Fly    65 LAYLGAEGSTADELKLGLGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRIFVTQRF 129
            :...||.|.|..:|..||..:..|..::..||.:.|.    .|::.|    .:..||.:|..:.|
Zfish    63 MLLPGAHGDTRRQLLNGLKYKKNGPYKMLRKLHKSLT----TKSNAD----IVTIANALFPNEGF 119

  Fly   130 KLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESLD-ADTSAILVN 193
            .:.:.:.....:||...:.:|:::.....|:.||.||:..|..||..::..:..| |.|..:.||
Zfish   120 SMKEDFLSANRENFLCESHSVDYSDPEAAAQSINDWVKNSTKGQIPSVVTADMFDTALTRLVAVN 184

  Fly   194 AIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTE---LKAKVVELPYTGTD 255
            :|:||..|:|.|...:|....|....|....|..|||...|..|:.:.   .|..|:||||.|..
Zfish   185 SIFFKGLWKSRFQPQSTKPRSFTAGDGNTYKVPMMSQLSVFNMGQASTPDGQKYIVIELPYHGNS 249

  Fly   256 IVFLIILPQEEQGLAIVEEKLMGIDLNEISS---QLRRRKVRVQLPKFKFEFDVPLQAALEELGI 317
            :...|.||.|:.  ..:...|..|..|.|.|   .:..|::|:.:|||..|.::.|:..|:.|||
Zfish   250 MSMFIALPTEDS--TPLSSILPHISTNTIQSWTKLMNPRRMRLLMPKFTVEQELDLETPLKALGI 312

  Fly   318 KKLFSPG-ANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVES----LTIGEEVF 377
            |.:|... |:...|  .||.:.:|:...||.|||||.||.||..|.:.:...|    :|:
Zfish   313 KDIFDQNKADFRHL--SSESIYVSKALQKAKIEVNEDGTKASATTSVILHARSSPPWVTV----- 370

  Fly   378 EFIADHPFFFAIK--DAQNTLFLGHVSQ 403
                |.||.|.|:  .:...||.|.:::
Zfish   371 ----DRPFLFLIRHNSSGTILFAGQINK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	111/383 (29%)
serpine2	NP_956478.1	PAI-1_nexin-1	26..395	CDD:239006	113/393 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6540
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.030