DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpinb1c

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	XP_006516771.1	Gene:	Serpinb1c / 380839	MGIID:	2445363	Length:	408	Species:	Mus musculus

Alignment Length:	405	Identity:	138/405 - (34%)
Similarity:	204/405 - (50%)	Gaps:	56/405 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLG 81
            |:.||.|           ||.:||..|.:|....|.:|||.||.:.||:.||||.||||.:|...
Mouse    37 LSSANNL-----------FALELFHTLNESNPTGNTIFSPVSISSALAMVYLGARGSTAAQLSKT 90

  Fly    82 LGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAA 146
            |..:.|  .::..:...|.|:.....||     ..||.|||::..:.:.....|...:.|.::|.
Mouse    91 LHFDSA--EDIHSQFQSLTAEVSKRGAS-----HTLKLANRLYGEKTYNFLPEYLASIQKTYSAD 148

  Fly   147 AENVNFTQKA-DTAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYAT 210
            ...|:|...: |..|.||.||:.||.::|::|.|...:|:.|..:||||.|||..||..|  .|.
Mouse   149 LALVDFQHASEDARKEINQWVKGQTEEKIQELFAVGVVDSMTKLVLVNATYFKGMWQKKF--MAR 211

  Fly   211 YASDFVNHGGRKV--SVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQGLAIVE 273
            ..:|......:||  :|..|..::...||.:.:||.||:|:||.|.::..:|:||::      :|
Mouse   212 DTTDAPFRLSKKVTKTVKMMYLKNNLPFGYIPDLKCKVLEMPYQGGELSMVILLPED------IE 270

  Fly   274 EKLMGIDLNEISSQLRRRKVR-----------VQLPKFKFEFDVPLQAALEELGIKKLFSPG-AN 326
            ::..|  |.||..||...|::           |:|||||.|....|.:.|.:||::.|||.. |:
Mouse   271 DETTG--LEEIEKQLTLEKLQECENLQNIDVCVKLPKFKMEESYILNSNLGQLGVQDLFSSSKAD 333

  Fly   327 LSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGA---TFIKVSVESLTIGEEVFEFIADHPFFFA 388
            ||.: .||..|.||::.||:.:||||:||....|   |.:...:..:       ||..||||.|.
Mouse   334 LSGM-SGSRDLFISKIVHKSYVEVNEEGTETDAAMPGTVVGCCLMPM-------EFTVDHPFLFF 390

  Fly   389 IK--DAQNTLFLGHV 401
            |:  ...:.||||.|
Mouse   391 IRHNPTAHVLFLGRV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	133/389 (34%)
Serpinb1c	XP_006516771.1	serpinB1_LEI	34..408	CDD:381028	138/405 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830