DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpina7

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_808588.3	Gene:	Serpina7 / 331535	MGIID:	3041197	Length:	426	Species:	Mus musculus

Alignment Length:	405	Identity:	113/405 - (27%)
Similarity:	187/405 - (46%)	Gaps:	37/405 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TCSLLLLQGLNLAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGA 70
            ||        :|...|...| |.|:..|.||..|:.:|:......||.|||.||...||:...|:
Mouse    40 TC--------HLPQQNATLY-KMPSINADFAFSLYRRLSVENPDLNIFFSPVSISVALAMLSFGS 95

  Fly    71 EGSTADEL--KLGLGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQ 133
            ..||..::  .||..|.....||:.:....|:....:.|     :..:|:..|.:|:.|:.|...
Mouse    96 GSSTQTQILEVLGFNLTDTPVTELQQGFQHLICSLNFPK-----NELELQMGNAVFIGQQLKPLA 155

  Fly   134 TYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFK 198
            .:.|.|...:.....:.:|:..:.....|||:||:||..:|..||  :.|..:...||||.|:|:
Mouse   156 KFLDDVKTLYETEVFSTDFSNVSAAQHKINSYVEKQTKGKIVGLI--QGLKLNIIMILVNYIHFR 218

  Fly   199 ADWQSSFPDYAT-YASDFVNHGGRKVSVDTMSQ-EDYFRFGELTELKAKVVELPYTGTDIVFLII 261
            |.|.:.|....| .:|:|.......|.|..|.| |.|:.:.:: ||...|:::.|: .:.:.|.:
Mouse   219 AQWANPFRVSKTEESSNFSVDKSTTVQVPMMHQLEQYYHYVDM-ELNCTVLQMDYS-ENALALFV 281

  Fly   262 LPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLFSPGAN 326
            ||:|.. :..||..:....|.:.:..|::..|.:.:|||.......|.:.|:::|::..|:..|:
Mouse   282 LPKEGH-MEWVEAAMSSKTLKKWNYLLQKGWVELFVPKFSISATYDLGSTLQKMGMRDAFAESAD 345

  Fly   327 LSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGE-----EVFEFIADHPFF 386
            ...:.:.| .|::|...|||::.:.|:| |..||:   ..|.||...|     .|...  |..|.
Mouse   346 FPGITEDS-GLKLSYAFHKAVLHIGEEG-TKEGAS---PEVGSLDQQEVPPLHPVIRL--DRAFL 403

  Fly   387 FAI--KDAQNTLFLG 399
            ..|  |..::.||||
Mouse   404 LMILEKRTRSVLFLG 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	106/380 (28%)
Serpina7	NP_808588.3	alpha-1-antitrypsin_like	57..419	CDD:239011	106/379 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100