DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and serpinc1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_878283.1	Gene:	serpinc1 / 321545	ZFINID:	ZDB-GENE-030131-264	Length:	450	Species:	Danio rerio

Alignment Length:	380	Identity:	127/380 - (33%)
Similarity:	201/380 - (52%)	Gaps:	16/380 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AQFASQLFGQLAKSQSG-RNIVFSPSSIRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKL 96
            ::||..||.|||:.:|. .||..||.||.|..|:..|||..:|.::|......:.. |.:.::::
Zfish    71 SRFALSLFKQLAEGKSNDENIFLSPISISTAFAMTKLGACNTTLEQLMKVFQFDTI-KEKTSDQV 134

  Fly    97 DQLLAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAK- 160
            ....||..........:..:|..|||:|..:.....:|:|.:....:.|....::|.:|.:.::
Zfish   135 HFFFAKLNCRLYRKKHETTELISANRLFGDKSTTFNETFQHISETVYGAKLMPLDFKEKPEASRI 199

  Fly   161 HINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSV 225
            .||.|:..:|..:|||.:...|:|.:|..:||||||||..|::.|........||......|..|
Zfish   200 TINEWIANKTENRIKDTLPEGSIDTNTILVLVNAIYFKGQWKNKFDKQNVMKLDFHVSPTHKCPV 264

  Fly   226 DTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRR 290
            ..|.||..|::.::.|.|.|::||||.|.||..::|||.|.   |.:.|.:..::|.::...|..
Zfish   265 PMMYQEKKFQYAKIPEDKVKILELPYNGGDITMVLILPIEG---ATLSEVVANMNLKKLVGWLHA 326

  Fly   291 RK---VRVQLPKFKFEFDVPLQAALEELGIKKLFSP-GANLSSLYQGSE--PLRISEVKHKAIIE 349
            .|   |.||:|:|:.|....|:..|.::|::.|||| .|:|..:...:|  .|.||:..|||.:|
Zfish   327 MKETTVAVQIPRFRVEDSFSLKEQLTKMGLEDLFSPANASLPGMVADAEGPNLFISDAYHKAFLE 391

  Fly   350 VNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIKDAQ-NTL-FLGHVS 402
            |||:|:.||.||.:..:..||.|..|  :|:||.||...|:::. |.| |.|.|:
Zfish   392 VNEEGSEASAATAVVATGRSLNIFRE--QFVADRPFLLFIRESSINALIFTGRVA 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	126/377 (33%)
serpinc1	NP_878283.1	antithrombin-III_like	62..443	CDD:239000	126/377 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2586
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8430
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.890