DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and SERPIND1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_000176.2	Gene:	SERPIND1 / 3053	HGNCID:	4838	Length:	499	Species:	Homo sapiens

Alignment Length:	427	Identity:	113/427 - (26%)
Similarity:	192/427 - (44%)	Gaps:	56/427 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVKATCS-------LLLLQGLN-LAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGR--NIVFS 55
            :||..|.|       |.|..|.: :...|.||        |:||..|: ::.|.|...  ||..:
Human    99 LSVSPTDSDVSAGNILQLFHGKSRIQRLNILN--------AKFAFNLY-RVLKDQVNTFDNIFIA 154

  Fly    56 PSSIRTGLALAYLGAEGSTADELKLGLG----LEGAGKTEVA------EKLDQLLAKGQWEKASG 110
            |..|.|.:.:..||.:|.|.:::...|.    :..:.|.|:.      .||...|.:..:...
Human   155 PVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHRLFRRNFGYT-- 217

  Fly   111 DEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIK 175
                  |:..|.:::.::|.:...::..|.:.:.|.|:..:|:..|..:| .|:.:.:.|...||
Human   218 ------LRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISK-TNNHIMKLTKGLIK 275

  Fly   176 DLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELT 240
            |  |.|::|..|..:::|.||||..|.:.||...|:..:|..:....|.|..|..:..|......
Human   276 D--ALENIDPATQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQ 338

  Fly   241 ELKAKVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFD 305
            ||...:::|.|.| .|..||::|.:..|:..:|.:|....:......:..|...|.|||||.|.:
Human   339 ELDCDILQLEYVG-GISMLIVVPHKMSGMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKN 402

  Fly   306 VPLQAALEELGIKKLFSPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGAT---FIKVSV 367
            ..|..:|:.:||:.||....|::.:  ..:.:.|...||:..|.|||:||.|:..|   |:.:|.
Human   403 YNLVESLKLMGIRMLFDKNGNMAGI--SDQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLST 465

  Fly   368 ESLTIGEEVFEFIADHPFFFAIKDAQNT--LFLGHVS 402
            :        ..|..|.||.|.|.:.:.:  ||:|.|:
Human   466 Q--------VRFTVDRPFLFLIYEHRTSCLLFMGRVA 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	102/386 (26%)
SERPIND1	NP_000176.2	HCII	62..497	CDD:239002	113/427 (26%)
		Chemotactic activity	68..79
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	73..97
		Glycosaminoglycan-binding site	192..212		5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020