DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpinb8

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001099418.1	Gene:	Serpinb8 / 288937	RGDID:	1309833	Length:	375	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	117/374 - (31%)
Similarity:	188/374 - (50%)	Gaps:	17/374 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 FASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLGLGLEGAGKTEVAEKLDQL 99
            ||..|...|.:....||:.|.|.|:.:.||:.||||:|:||.::...|||.|.|  :|.:....|
  Rat    11 FAISLLKILGEEDKSRNLFFCPMSVSSALAMVYLGAKGNTATQMSQVLGLSGDG--DVHQGFQTL 73

  Fly   100 LAKGQWEKASGDEDVPKLKYANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKAD-TAKHIN 163
            ||:   ...||.:.:  ||.|.|:|..:......|:::...|.:.|..|.::|.:..: ..|.||
  Rat    74 LAE---VNKSGTQYL--LKSACRLFGEESCDFLSTFKESCQKFYQAGIEEMSFVKDTEGCRKRIN 133

  Fly   164 SWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTM 228
            .||.|:|..:|.::::|.::...|..:||||:|||..|::.|....|....|..:...|.:|..|
  Rat   134 DWVLEKTEGKISEVLSPGTVCPLTKLVLVNAMYFKGKWKAQFDRKYTRGMPFKTNQEEKKTVQMM 198

  Fly   229 SQEDYFRFGELTELKAKVVELPYTGTDIVFLIILPQEEQGLAIVEEKLMGIDLNEISS--QLRRR 291
            .:...|:...:.|:.|:|:.|||...::..:::||.|...|.:||:.|....|...::  .|...
  Rat   199 FKHAKFKMAHVDEVNAQVLALPYAEDELSMVVLLPDESSDLTVVEKALTYEKLRAWTNPETLTES 263

  Fly   292 KVRVQLPKFKFEFDVPLQAALEELGIKKLF-SPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGT 355
            ||:|..|:.|.|....|:..|:.||:...| ...|:.|.: ...:.:.:|:|.||..:||||:||
  Rat   264 KVQVFFPRLKLEESYDLETVLQSLGMTDAFEETKADFSGM-TSKKNVPVSKVAHKCFVEVNEEGT 327

  Fly   356 TASGATFIKVSVESLTIGEEVFEFIADHPFFFAI--KDAQNTLFLGHVS 402
            .|:..|.:..:..|..|..   .|.||.||.|.|  :...:.||.|..|
  Rat   328 EAAATTAVIRNTRSCRIEP---RFCADRPFLFFIWHQKTSSILFCGRFS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	116/371 (31%)
Serpinb8	NP_001099418.1	SERPIN	4..375	CDD:294093	117/374 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.930