DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpine1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_036752.2	Gene:	Serpine1 / 24617	RGDID:	3249	Length:	402	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	122/422 - (28%)
Similarity:	195/422 - (46%)	Gaps:	42/422 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVKATC---SLLLLQGLNLAMANTLNYSKSPAGEAQFASQ-------LFGQLAKSQSGRNIVFS 55
            ||...||   .|:|:.|...|         ||..|:..|.|       :|..:.::...||:|||
  Rat     3 MSSALTCLTLGLVLVFGKGFA---------SPLPESHTAQQATNFGVKVFQHVVQASKDRNVVFS 58

  Fly    56 PSSIRTGLALAYLGAEGSTADELK--LGLGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPKLK 118
            |..:.:.||:..|...|.|..:::  :|..:...|......||.:.| .|.|.|       .::.
  Rat    59 PYGVSSVLAMLQLTTAGKTRQQIQDAMGFNISERGTAPALRKLSKEL-MGSWNK-------NEIS 115

  Fly   119 YANRIFVTQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESL 183
            .|:.|||.:..:|.|.:.....|.|....:.|:|::.......||.|||..|...|.||:|..::
  Rat   116 TADAIFVQRDLELVQGFMPHFFKLFRTTVKQVDFSEMERARFIINDWVERHTKGMISDLLAKGAV 180

  Fly   184 DADTSAILVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTE---LKAK 245
            :..|..:||||:||...|::.|.:.:|:...|....|..:||..|:|.:.|.:.|.|.   .:..
  Rat   181 NELTRLVLVNALYFNGQWKTPFLEASTHQRLFHKSDGSTISVPMMAQNNKFNYTEFTTPDGHEYD 245

  Fly   246 VVELPYTGTDIVFLIILP-QEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQ 309
            ::||||.|..:...|..| :::..|:.:...|....:.:..|.:.|....:.||||..|.:|.|:
  Rat   246 ILELPYHGETLSMFIAAPFEKDVPLSAITNILDAELIRQWKSNMTRLPRLLILPKFSLETEVDLR 310

  Fly   310 AALEELGIKKLF-SPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIG 373
            ..||:||:..:| |..|:.:|| ...|.|.:::...|..|||||.||.||.:|.|.||......
  Rat   311 GPLEKLGMTDIFSSTQADFTSL-SDQEQLSVAQALQKVKIEVNESGTVASSSTAILVSARMAPT- 373

  Fly   374 EEVFEFIADHPFFFAIK--DAQNTLFLGHVSQ 403
                |.:.|..|.|.::  ..:..||:|.:.:
  Rat   374 ----EMVLDRSFLFVVRHNPTETILFMGQLME 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	112/385 (29%)
Serpine1	NP_036752.2	serpin	29..402	CDD:422956	111/387 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020