Protein Alignment Spn42De and SERPINB1

DIOPT Version :9

• Sequence 1: NP_610246.3
• Gene: Spn42De / 35602
• FlyBaseID: FBgn0033115
• Length: 404
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 403
• Identity: 137/403 - (33%)
• Similarity: 212/403 - (52%)
• Gaps: 46/403 - (11%)

  Fly    17 LAMANTLNYSKSPAGEAQFASQLFGQLAKSQSGRNIVFSPSSIRTGLALAYLGAEGSTADELKLG 81
            |:.|||           :||..||..|:::....||..||.||.:.:|:.:||..|:||.:|
Human     4 LSSANT-----------RFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQL--- 54

  Fly    82 LGLEGAGKTEVAEKLDQLLAKGQWEKASGDEDVPK------LKYANRIFVTQRFKLTQTYQDLVS 140
                  .||.....::::.::.|    |.:.|:.|      ||.|||::..:.:.....:.....
Human    55 ------SKTFHFNTVEEVHSRFQ----SLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQ 109

  Fly   141 KNFAAAAENVNFTQKA-DTAKHINSWVEEQTHQQIKDLIAPESLDADTSAILVNAIYFKADWQSS 204
            |.:.|...:|:|...: |..|.||.||:.||..:|.:|:|...:|..|..:||||||||.:|:..
Human   110 KTYGADLASVDFQHASEDARKTINQWVKGQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDK 174

  Fly   205 FPDYATYASDF-VNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTDIVFLIILP----Q 264
            |...||..:.| :|...|| :|..|.|:..|.:|.:.:||.:|:||||.|.::..:|:||    .
Human   175 FMKEATTNAPFRLNKKDRK-TVKMMYQKKKFAYGYIEDLKCRVLELPYQGEELSMVILLPDDIED 238

  Fly   265 EEQGLAIVEEKLMGIDLNEIS--SQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKLF-SPGAN 326
            |..||..:||:|....|:|.:  ..|...:|.|.||:||.|....|.:.|..||::.|| |..|:
Human   239 ESTGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKAD 303

  Fly   327 LSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGATFIKVSVESLTIGEEVFEFIADHPFFFAIK- 390
            ||.: .|:..:.||::.||:.:||||:||.|:.|| ..::...:.:.||  .|.|||||.|.|:
Human   304 LSGM-SGARDIFISKIVHKSFVEVNEEGTEAAAAT-AGIATFCMLMPEE--NFTADHPFLFFIRH 364

  Fly   391 -DAQNTLFLGHVS 402
             .:.:.||||..|
Human   365 NSSGSILFLGRFS 377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	132/386 (34%)
SERPINB1	NP_109591.1	SERPIN	4..379	CDD:294093	137/403 (34%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		13/27 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BBFJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	1	1.000	-	-		FOG0000050
OrthoInspector	1	1.000	-	-		mtm8652
orthoMCL	1	0.900	-	-		OOG6_100128
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.830