DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn42De and Serpind1

DIOPT Version :9

Sequence 1:	NP_610246.3	Gene:	Spn42De / 35602	FlyBaseID:	FBgn0033115	Length:	404	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	412	Identity:	111/412 - (26%)
Similarity:	190/412 - (46%)	Gaps:	49/412 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLLLQGLN-LAMANTLNYSKSPAGEAQFASQLFGQLAKSQ--SGRNIVFSPSSIRTGLALAYLGA 70
            |.|.||.: :...|.||        |:||..|: ::.|.|  :..|:..:|..|.|.:.:..||.
Mouse    93 LQLFQGKSRIQRLNILN--------AKFAFNLY-RVLKDQATTSDNLFIAPVGISTAMGMISLGL 148

  Fly    71 EGSTADELKLGLG----LEGAGKTEVA------EKLDQLLAKGQWEKASGDEDVPKLKYANRIFV 125
            .|.|.:|:...|.    :..:.|.||.      .||...|.:..:...        |:..|.:::
Mouse   149 RGETHEEVHSVLHFRDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYT--------LRSVNGLYI 205

  Fly   126 TQRFKLTQTYQDLVSKNFAAAAENVNFTQKADTAKHINSWVEEQTHQQIKDLIAPESLDADTSAI 190
            .::|.:.:.::..:.:.:.|.|:..||...|..:| .|:.:.:.|...||:  |.|::|..|..:
Mouse   206 QKQFPIREDFKAAMREFYFAEAQEANFPDPAFISK-ANNHILKLTKGLIKE--ALENIDPATQML 267

  Fly   191 LVNAIYFKADWQSSFPDYATYASDFVNHGGRKVSVDTMSQEDYFRFGELTELKAKVVELPYTGTD 255
            ::|.||||..|.:.||...|:..:|..:....|.|..|..:..|......||...:::|.|.| .
Mouse   268 ILNCIYFKGTWVNKFPVEMTHNHNFRLNEREVVKVSMMQTKGNFLAANDQELDCDILQLEYVG-G 331

  Fly   256 IVFLIILPQEEQGLAIVEEKLMGIDLNEISSQLRRRKVRVQLPKFKFEFDVPLQAALEELGIKKL 320
            |..||::|::..|:..:|.:|....:......:..|...|.|||||.|.:..|...|:.:||.||
Mouse   332 ISMLIVVPRKLSGMKTLEAQLTPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKL 396

  Fly   321 FSPGANLSSLYQGSEPLRISEVKHKAIIEVNEKGTTASGAT---FIKVSVESLTIGEEVFEFIAD 382
            |:...|:|.:  ..:.:.|...||::.|.|||:||.|:..|   |:.:|.:        ..|..|
Mouse   397 FNKNGNMSGI--SDQRIAIDLFKHQSTITVNEEGTQAAAVTTVGFMPLSTQ--------VRFTVD 451

  Fly   383 HPFFFAIKDAQNT--LFLGHVS 402
            .||.|.:.:.:.:  ||:|.|:
Mouse   452 RPFLFLVYEHRTSCLLFMGKVT 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn42De	NP_610246.3	SERPIN	31..401	CDD:238101	103/386 (27%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	111/412 (27%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020